{"id":"W2091406815","doi":"10.1074/jbc.m706424200","title":"A Chimera of Interleukin 2 and a Binding Variant of Aerolysin Is Selectively Toxic to Cells Displaying the Interleukin 2 Receptor","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"PROTO Manufacturing (Canada)","funders":"","keywords":"Chimera (genetics); Interleukin-1 receptor; Interleukin-4 receptor; Interleukin 1β; Aerolysin; Interleukin; Receptor; Interleukin 2; Chemistry; Interleukin 4; Interleukin 15; Molecular biology; Cell biology; Biology; Immunology; Biochemistry; Cytokine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001015817,0.0001733937,0.0004796543,0.00006976644,0.00007478397,0.00001037323,0.0003615915,0.0002917655,0.0004746534],"category_scores_gemma":[0.0002064792,0.00009983338,0.0001820289,0.0001909539,0.0002040931,0.00004351946,0.0001510714,0.0005185413,0.00000641415],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005003757,"about_ca_system_score_gemma":0.00004068173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001001247,"about_ca_topic_score_gemma":8.192429e-7,"domain_scores_codex":[0.9986508,0.00008385786,0.0007539979,0.0001801885,0.00005728157,0.0002739111],"domain_scores_gemma":[0.9987666,0.000292097,0.0006288928,0.0001474405,0.0001195535,0.00004543911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006912723,0.0001327699,0.0003817751,0.00002349914,0.0002023198,0.000006887336,0.0007513348,6.532269e-7,0.9946629,0.00002948506,0.0002488509,0.002868212],"study_design_scores_gemma":[0.00061356,0.0007333847,0.001654777,0.0001581372,0.0000342279,0.0002553731,0.0009961738,8.891795e-7,0.9937144,0.00005046137,0.001677086,0.0001115592],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974256,0.0008550151,0.00104709,0.0001485143,0.0002148955,0.00009689909,0.00003295638,0.000005404715,0.0001736327],"genre_scores_gemma":[0.9986363,0.0001187391,0.0008383301,0.000127476,0.00004992355,0.000001555597,0.000002985656,0.000008102616,0.0002165859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002756653,"threshold_uncertainty_score":0.5197122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01277209875495727,"score_gpt":0.2382533276528218,"score_spread":0.2254812288978645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}