{"id":"W2091406815","doi":"10.1074/jbc.m706424200","title":"A Chimera of Interleukin 2 and a Binding Variant of Aerolysin Is Selectively Toxic to Cells Displaying the Interleukin 2 Receptor","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"PROTO Manufacturing (Canada)","funders":"","keywords":"Chimera (genetics); Interleukin-1 receptor; Interleukin-4 receptor; Interleukin 1β; Aerolysin; Interleukin; Receptor; Interleukin 2; Chemistry; Interleukin 4; Interleukin 15; Molecular biology; Cell biology; Biology; Immunology; Biochemistry; Cytokine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001382251,0.0003662247,0.0002583801,0.0001319687,0.0001189788,0.0003475939,0.000247268,0.0004482487,0.0008867182],"category_scores_gemma":[0.0001024775,0.0001767357,0.000301687,0.0001620143,0.0002579838,0.0002020029,0.0002675104,0.0009365648,0.0003398981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004329605,"about_ca_system_score_gemma":0.000162275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004449401,"about_ca_topic_score_gemma":0.000344608,"domain_scores_codex":[0.9998266,0.00003585534,0.00001770365,0.0000336832,0.00004325532,0.00004291457],"domain_scores_gemma":[0.9998907,0.00002208453,0.00003223574,0.00001787645,0.000007155773,0.00002999709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001031047,0.00002214634,0.00008860521,0.000008739084,0.000005606236,0.00005319145,0.000009698188,0.0001042967,0.9992107,0.0001471279,0.00001679354,0.0002299134],"study_design_scores_gemma":[0.00005445921,0.0003074023,0.001796272,0.000004782218,0.00002559203,0.00070216,0.0000268312,0.001905799,0.9914996,0.00005643319,0.003611543,0.000009086478],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958441,0.0003279953,0.002656759,0.00008488419,0.00002199473,0.00002275323,0.0001981568,0.00005581859,0.0007875494],"genre_scores_gemma":[0.994293,0.0002447774,0.002695746,0.00005468926,0.000006973977,0.00002361893,0.0005699354,0.00002635724,0.002084976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008867182,"threshold_uncertainty_score":0.003141284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01277209875495727,"score_gpt":0.2382533276528218,"score_spread":0.2254812288978645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}