{"id":"W2091407155","doi":"10.1097/hjh.0b013e3282f0ca68","title":"Kallikrein gene ‘knock-down’ by small interfering RNA transfection induces a profibrotic phenotype in rat mesangial cells","year":2008,"lang":"en","type":"article","venue":"Journal of Hypertension","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Kallikrein; Small interfering RNA; Bradykinin; Transfection; Molecular biology; Endocrinology; Urokinase receptor; Plasminogen activator; Internal medicine; Gene silencing; Receptor; Messenger RNA; Biology; Cell biology; Medicine; Gene; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003374931,0.0004319579,0.0004431549,0.0002445101,0.0001718305,0.0003536214,0.000270747,0.0003922676,0.00124733],"category_scores_gemma":[0.0001667984,0.0002424916,0.0003815615,0.0002046877,0.0002874306,0.0002151754,0.0001915218,0.0007440464,0.0006076518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002168885,"about_ca_system_score_gemma":0.0002159299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005150572,"about_ca_topic_score_gemma":0.0009144337,"domain_scores_codex":[0.9996748,0.00003991069,0.000051753,0.00008019002,0.00009080292,0.00006264508],"domain_scores_gemma":[0.9997783,0.00005624101,0.00006997778,0.00003420787,0.00002681833,0.00003446564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003884898,0.00002064157,0.00004466729,0.00002748963,0.000003993225,0.00002786717,0.0000107765,0.00002418375,0.9993753,0.00004238365,0.00002905018,0.0003548435],"study_design_scores_gemma":[0.00001945195,0.000240611,0.002064456,0.000004253662,0.00002288215,0.0001213164,0.00001484596,0.000658571,0.994885,0.0000231694,0.001940265,0.000005088379],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816306,0.002491598,0.0120436,0.0002160985,0.0001302268,0.0001066872,0.0009314272,0.000449327,0.002000505],"genre_scores_gemma":[0.9791173,0.001897085,0.0129182,0.0001433645,0.00003637564,0.0001935271,0.00128189,0.00006733732,0.004344779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00124733,"threshold_uncertainty_score":0.004172683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03928342294828772,"score_gpt":0.229421791686181,"score_spread":0.1901383687378933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}