{"id":"W2091412980","doi":"10.1074/jbc.m802869200","title":"Resveratrol Inhibits Cardiac Hypertrophy via AMP-activated Protein Kinase and Akt","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":245,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; European Commission; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; Agence Nationale de la Recherche; Heart and Stroke Foundation of Canada","keywords":"Resveratrol; Protein kinase B; AMPK; Protein kinase A; AMP-activated protein kinase; Cell biology; Kinase; PI3K/AKT/mTOR pathway; Chemistry; Myocyte; Phosphorylation; Biology; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001767116,0.0001961101,0.0002885869,0.00001581504,0.00009205133,0.00001385716,0.0001834861,0.0003042345,0.00004047414],"category_scores_gemma":[0.0004413288,0.0001458851,0.0001987718,0.00007794829,0.0002436061,0.000005380361,0.000108065,0.0002624858,0.000003070151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002203199,"about_ca_system_score_gemma":0.00009344291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001789226,"about_ca_topic_score_gemma":4.924104e-8,"domain_scores_codex":[0.9989073,0.00007707762,0.000352763,0.0002653866,0.0001711231,0.000226355],"domain_scores_gemma":[0.9990909,0.0000211178,0.0002443064,0.0002179409,0.0001782841,0.0002474645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004930664,0.0001090883,0.002670066,0.00002048957,0.0000699856,0.00008413223,0.00001087354,0.000007216879,0.9953296,6.192057e-7,0.0008927237,0.0003121672],"study_design_scores_gemma":[0.0005944885,0.0003108379,0.0006912843,0.00002798259,0.00001631547,0.0003026433,0.0000101709,0.000001302734,0.9888379,0.00004642592,0.008972591,0.0001880523],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970402,0.002346389,0.0001266952,0.0001042295,0.00006052799,0.00009513672,0.00002167906,0.00001060884,0.0001946035],"genre_scores_gemma":[0.9980495,0.0001618563,0.0008351613,0.0001444049,0.000591627,0.000007786157,0.00003148982,0.0000150388,0.0001631193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008079867,"threshold_uncertainty_score":0.594902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0216098940061603,"score_gpt":0.2324167600337181,"score_spread":0.2108068660275578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}