{"id":"W2091451344","doi":"10.1186/1752-0509-1-17","title":"An in silico model of the ubiquitin-proteasome system that incorporates normal homeostasis and age-related decline","year":2007,"lang":"en","type":"article","venue":"BMC Systems Biology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Health Canada; Ottawa Public Health","funders":"Biotechnology and Biological Sciences Research Council; Engineering and Physical Sciences Research Council; Medical Research Council; Canadian Institutes of Health Research; Unilever","keywords":"Proteasome; Ubiquitin; Proteolysis; Cell biology; Systems biology; In silico; Biology; Protein degradation; Ubiquitin ligase; Chemistry; Biochemistry; Computational biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001492187,0.000237503,0.0003970127,0.0001149131,0.00008268602,0.00001941866,0.0003771875,0.0004846169,0.000002071049],"category_scores_gemma":[0.00006880031,0.0001738322,0.00008662001,0.0001805068,0.0002700356,0.000007945481,0.0002499158,0.0001508602,0.000002568983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002905244,"about_ca_system_score_gemma":0.0001041235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003342597,"about_ca_topic_score_gemma":0.0006563438,"domain_scores_codex":[0.9980344,0.0004024356,0.0005989,0.0004495823,0.0001139788,0.0004007336],"domain_scores_gemma":[0.998852,0.00005075756,0.000353529,0.0005477432,0.00008603685,0.0001099888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001850908,0.00006329999,0.1474784,0.0002901738,0.00003322457,0.000004742145,0.0001229385,0.0009199031,0.8464544,0.003669627,0.00001202499,0.0007660967],"study_design_scores_gemma":[0.00256925,0.0009202486,0.03322555,0.0003119033,0.00004596432,0.0002517276,0.001818327,0.01790535,0.9410732,0.0005138476,0.0006522792,0.0007122983],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931791,0.002746949,0.002353629,0.00002022922,0.0002446264,0.0007649381,0.0001054839,0.00002678388,0.0005582289],"genre_scores_gemma":[0.9990978,0.00004940389,0.0004173825,0.00005106692,0.0001190661,0.00005727888,0.0001006846,0.00002742926,0.00007987052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1142529,"threshold_uncertainty_score":0.7088673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0270920110565735,"score_gpt":0.2610538663135684,"score_spread":0.2339618552569949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}