{"id":"W2091489738","doi":"10.1080/13506120500032295","title":"Multiple ligand binding sites on Aβ(1–40) fibrils","year":2005,"lang":"en","type":"article","venue":"Amyloid","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McGill University","keywords":"Thioflavin; Benzothiazole; Fibril; Chemistry; Peptide; Amyloid (mycology); Ligand (biochemistry); Monomer; Congo red; Binding site; Biophysics; Biochemistry; Receptor; Biology; Medicine; Alzheimer's disease; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002556116,0.0003424216,0.0004181112,0.0002241371,0.0003968051,0.0003811816,0.0003600876,0.0004912316,0.001988928],"category_scores_gemma":[0.0003156544,0.0002926658,0.0002799261,0.0001204428,0.0002859879,0.0003531523,0.0002625335,0.0003660226,0.0007254653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000385781,"about_ca_system_score_gemma":0.0002112944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001137673,"about_ca_topic_score_gemma":0.001597058,"domain_scores_codex":[0.9997249,0.00005130148,0.00001202184,0.00008579362,0.00007120094,0.0000548038],"domain_scores_gemma":[0.9997547,0.00009451622,0.00004100023,0.0000182319,0.0000276425,0.00006387314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008012558,0.00001470337,0.0001795729,0.00002557697,0.000003981654,0.00004576386,0.00001249777,0.00006010224,0.9982192,0.00006805146,0.00001812349,0.001272425],"study_design_scores_gemma":[0.00004634097,0.0008085624,0.01302902,0.00002292286,0.00003704962,0.001503552,0.00005215854,0.001814532,0.9800062,0.0002109528,0.002449534,0.00001918403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877169,0.003689747,0.005329411,0.00008560824,0.00001491598,0.00002588131,0.00005593349,0.00006572412,0.00301594],"genre_scores_gemma":[0.993937,0.0007257993,0.003815089,0.00006216273,0.00001339773,0.00002037051,0.00006529808,0.000009576915,0.001351222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001988928,"threshold_uncertainty_score":0.006653607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03566642839228181,"score_gpt":0.3175976866812115,"score_spread":0.2819312582889297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}