{"id":"W2091503047","doi":"10.1186/1471-2121-15-29","title":"IRE1 inhibition perturbs the unfolded protein response in a pancreatic β-cell line expressing mutant proinsulin, but does not sensitize the cells to apoptosis","year":2014,"lang":"en","type":"article","venue":"BMC Cell Biology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; University of Cambridge; MannKind Corporation","keywords":"Proinsulin; Unfolded protein response; Endoplasmic reticulum; XBP1; Endoplasmic-reticulum-associated protein degradation; Cell biology; Biology; ATF6; Molecular biology; RNA splicing; Insulin; Gene; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002552852,0.0005870792,0.0004536955,0.0002536168,0.0001392628,0.0004065777,0.000358077,0.000378508,0.001858817],"category_scores_gemma":[0.0001162103,0.0001962526,0.0003623777,0.0002824522,0.0002367655,0.0002110208,0.0001673568,0.00115114,0.0007197614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002208587,"about_ca_system_score_gemma":0.0002107257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002316758,"about_ca_topic_score_gemma":0.0002097693,"domain_scores_codex":[0.9997516,0.0000207913,0.00004733132,0.00006695755,0.0000729034,0.00004041233],"domain_scores_gemma":[0.9997535,0.0000472042,0.00008775565,0.00004479077,0.00002221131,0.00004453037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000097062,0.00005713184,0.00007122864,0.00002008922,0.000003792557,0.00002411265,0.000005755427,0.00002605603,0.9993912,0.00001455114,0.00001999426,0.0002689939],"study_design_scores_gemma":[0.00001479792,0.00029059,0.001169855,0.000003852141,0.00001025492,0.000112273,0.000009948802,0.0003097867,0.9972557,0.00000953004,0.0008112345,0.000002289523],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945782,0.000936691,0.002187307,0.0001025876,0.0000773493,0.00005158779,0.0008283547,0.0001641275,0.001073767],"genre_scores_gemma":[0.9845555,0.001351137,0.006676186,0.0001290284,0.00002889388,0.0001467302,0.003158135,0.0001111205,0.003843315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001858817,"threshold_uncertainty_score":0.006218433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007997981410753493,"score_gpt":0.2221817596157776,"score_spread":0.2141837782050241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}