{"id":"W2091533593","doi":"10.4161/auto.23568","title":"Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells","year":2013,"lang":"en","type":"article","venue":"Autophagy","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Eye Institute","keywords":"Autophagy; Biology; Trabecular meshwork; Cell biology; Flux (metallurgy); Biochemistry; Materials science; Apoptosis; Neuroscience; Metallurgy; Glaucoma","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001723652,0.000170716,0.0003036075,0.0002805154,0.0002406782,0.0003070983,0.00008339372,0.0002647533,0.001127277],"category_scores_gemma":[0.000123362,0.0001366212,0.0002173869,0.0002296089,0.0003201481,0.0002818153,0.0001891407,0.0003522901,0.0001692536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002217919,"about_ca_system_score_gemma":0.00021697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001322132,"about_ca_topic_score_gemma":0.0014757,"domain_scores_codex":[0.9998738,0.00002007474,0.00002206363,0.00002277603,0.0000343506,0.00002696176],"domain_scores_gemma":[0.999876,0.00001927979,0.00003741512,0.00001612042,0.00002285485,0.00002820387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000192334,0.00001961814,0.00107483,0.00004113404,0.000007639323,0.0001601141,0.0000588029,0.00002873279,0.997794,0.00007795967,0.00001947556,0.0005253806],"study_design_scores_gemma":[0.00005906466,0.0007939729,0.07901102,0.00001891897,0.00004301342,0.002003249,0.0003913432,0.001090946,0.9135457,0.0003352073,0.002688965,0.00001870385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964597,0.001031542,0.001371012,0.00006700205,0.00002426973,0.00001181794,0.0002647916,0.00002038876,0.0007495734],"genre_scores_gemma":[0.9975423,0.000495332,0.0007805173,0.00003875136,0.00001036482,0.00002026444,0.0002711321,0.000005617238,0.0008357425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001322132,"threshold_uncertainty_score":0.003771126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009579818133166593,"score_gpt":0.2423094746301177,"score_spread":0.2327296564969511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}