{"id":"W2091533593","doi":"10.4161/auto.23568","title":"Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells","year":2013,"lang":"en","type":"article","venue":"Autophagy","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Eye Institute","keywords":"Autophagy; Biology; Trabecular meshwork; Cell biology; Flux (metallurgy); Biochemistry; Materials science; Apoptosis; Neuroscience; Metallurgy; Glaucoma","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000151896,0.0002766903,0.0004170582,0.0002054852,0.00007863121,0.00005273457,0.0001357169,0.000176996,0.00232961],"category_scores_gemma":[0.00005188486,0.0002493568,0.0001026264,0.0003168035,0.0001263484,0.000251961,0.00003122726,0.0002161297,0.0003653527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000744666,"about_ca_system_score_gemma":0.0001456908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002164179,"about_ca_topic_score_gemma":0.000006705822,"domain_scores_codex":[0.9982924,0.0001175985,0.0004052597,0.0004879736,0.000290273,0.0004064237],"domain_scores_gemma":[0.9989315,0.0001110249,0.0001151197,0.0004363963,0.00008295883,0.000323047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000262608,0.001261271,0.01079043,0.0001955112,0.0002657688,0.0003245488,0.001063901,0.00002360538,0.9450681,0.003053514,0.001970008,0.0357208],"study_design_scores_gemma":[0.003234778,0.0001712335,0.6582506,0.00009815801,0.00007589942,0.00001790644,0.0001476153,0.002740756,0.3326178,0.001481883,0.0009135882,0.0002498018],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946926,0.001660163,0.000202753,0.0005241648,0.00009960956,0.0008971244,0.00001045147,0.0001439664,0.001769145],"genre_scores_gemma":[0.9958811,0.0001375891,0.001257265,0.001055217,0.00009265268,0.0001622326,0.0000820213,0.00004276492,0.001289103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6474601,"threshold_uncertainty_score":0.9999959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009579818133166593,"score_gpt":0.2423094746301177,"score_spread":0.2327296564969511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}