{"id":"W2091547991","doi":"10.1016/j.clinthera.2007.06.002","title":"Immunogenicity and tolerability of an investigational formulation of interferon-β1a: 24- and 48-week interim analyses of a 2-year, single-arm, historically controlled, phase IIIb study in adults with multiple sclerosis","year":2007,"lang":"en","type":"article","venue":"Clinical Therapeutics","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Merck KGaA","keywords":"Medicine; Tolerability; Immunogenicity; Interim; Interim analysis; Multiple sclerosis; Pharmacology; Internal medicine; Immunology; Adverse effect; Clinical trial; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002259508,0.0001931747,0.001225384,0.0001875294,0.00004020403,0.000007409702,0.00011505,0.000121588,0.00001041901],"category_scores_gemma":[0.001731374,0.0001416862,0.0001263888,0.000295544,0.0008683562,0.0001201125,0.0001086595,0.0002992703,1.138946e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009767493,"about_ca_system_score_gemma":0.00009188555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000241616,"about_ca_topic_score_gemma":0.0005781855,"domain_scores_codex":[0.9968549,0.0003391786,0.001764694,0.0003673483,0.0004628607,0.0002110328],"domain_scores_gemma":[0.9963449,0.001924149,0.0005552234,0.0003594168,0.0006574864,0.0001587772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.06558558,0.01890101,0.7985501,0.0002103348,0.0007861301,0.000002047759,0.00243621,0.00001170938,0.08448318,0.00001030527,0.00000230893,0.02902112],"study_design_scores_gemma":[0.05651389,0.02483323,0.9014545,0.000418446,0.0002861521,0.000001378042,0.001661717,0.006705915,0.00792586,0.00005632827,0.000007024699,0.0001355601],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972561,0.00058256,0.000678698,0.00007217934,0.00005157053,0.001292858,0.0000286683,0.00001131031,0.00002606191],"genre_scores_gemma":[0.9957245,0.0002220567,0.003920199,0.00005062702,0.00003087653,0.00001739178,0.00001394555,0.00001580813,0.00000459385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1029044,"threshold_uncertainty_score":0.5777797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3748171886884401,"score_gpt":0.4608669599295451,"score_spread":0.08604977124110502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}