{"id":"W2091547991","doi":"10.1016/j.clinthera.2007.06.002","title":"Immunogenicity and tolerability of an investigational formulation of interferon-β1a: 24- and 48-week interim analyses of a 2-year, single-arm, historically controlled, phase IIIb study in adults with multiple sclerosis","year":2007,"lang":"en","type":"article","venue":"Clinical Therapeutics","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Merck KGaA","keywords":"Medicine; Tolerability; Immunogenicity; Interim; Interim analysis; Multiple sclerosis; Pharmacology; Internal medicine; Immunology; Adverse effect; Clinical trial; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004628919,0.001065929,0.001468486,0.0004133029,0.000630796,0.0008310463,0.0006425143,0.001395445,0.001143703],"category_scores_gemma":[0.003225488,0.0006517355,0.001589786,0.0004016326,0.001127722,0.001494204,0.000322012,0.002979925,0.0004331958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006522482,"about_ca_system_score_gemma":0.0006669889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00084599,"about_ca_topic_score_gemma":0.0006834125,"domain_scores_codex":[0.9989115,0.0005104556,0.0000772323,0.0001559836,0.0001541524,0.0001905346],"domain_scores_gemma":[0.9979761,0.0005513534,0.0005880446,0.0003394589,0.0001608557,0.000384162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8466784,0.03179858,0.03844117,0.0001246767,0.0009068838,0.0001695461,0.0004609994,0.001513837,0.03991041,0.0001080502,0.0005605685,0.03932697],"study_design_scores_gemma":[0.1260256,0.6960655,0.1583612,0.00002318487,0.001247838,0.0004789468,0.000188092,0.002323265,0.01427029,0.0001928212,0.0007451241,0.00007805085],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992906,0.0002229685,0.0001339014,0.0000300903,0.00001364498,0.00005659322,0.0001035536,0.00001150619,0.0001371517],"genre_scores_gemma":[0.9987734,0.00008900207,0.0002492635,0.0000906823,0.00004878921,0.0001194511,0.0003835508,0.000009323694,0.0002365044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004628919,"threshold_uncertainty_score":0.02448034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3748171886884401,"score_gpt":0.4608669599295451,"score_spread":0.08604977124110502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}