{"id":"W2091556818","doi":"10.1074/jbc.m111.307355","title":"Characterization of Spindle Checkpoint Kinase Mps1 Reveals Domain with Functional and Structural Similarities to Tetratricopeptide Repeat Motifs of Bub1 and BubR1 Checkpoint Kinases","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Wilfrid Laurier University; Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research; Fondation des Etoiles; Wellcome Trust","keywords":"BUB1; Kinetochore; Tetratricopeptide; Spindle checkpoint; Biology; Chromosome segregation; Mitosis; Centromere; Cell biology; Cell cycle checkpoint; Kinase; G2-M DNA damage checkpoint; Cell cycle; Genetics; Chromosome; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002131926,0.0001740861,0.0003340311,0.00003576613,0.0000369598,0.00001051226,0.000112922,0.0001948013,0.0000451725],"category_scores_gemma":[0.0001241105,0.0001197931,0.00008983573,0.00007179636,0.000212974,0.0000109737,0.0001017322,0.0001302482,1.084725e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001364961,"about_ca_system_score_gemma":0.00004788914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007599824,"about_ca_topic_score_gemma":0.000001780443,"domain_scores_codex":[0.9989606,0.00003252679,0.0005243627,0.0002216224,0.0001081919,0.0001527601],"domain_scores_gemma":[0.9990153,0.00001403046,0.0004568824,0.0001508128,0.0002348098,0.0001281969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000616076,0.00006733302,0.02294634,0.000110012,0.00006261611,0.000007701883,0.00006710432,0.000003309775,0.975843,0.000009835323,0.00001666497,0.0002500153],"study_design_scores_gemma":[0.0005063436,0.0008932794,0.1061903,0.000080502,0.00002888842,0.0002663334,0.000195454,0.000002889381,0.8914822,0.0001132112,0.0001052559,0.0001352703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986402,0.0003918822,0.0006154462,0.00004341889,0.00002935401,0.00009761617,0.00006692257,0.000002769106,0.0001123483],"genre_scores_gemma":[0.9966863,0.0003466618,0.00264456,0.00006322502,0.0001348057,0.000002793433,0.00005353264,0.000009557152,0.00005853692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08436076,"threshold_uncertainty_score":0.4885019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01679868492964528,"score_gpt":0.2143720798047499,"score_spread":0.1975733948751046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}