{"id":"W2091580200","doi":"10.1371/journal.pbio.0050263","title":"Nicotinamide Riboside Kinase Structures Reveal New Pathways to NAD+","year":2007,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":159,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Cancer Institute; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Wellcome Trust; Ontario Genomics; Genome Canada; GlaxoSmithKline; Ontario Innovation Trust; University of Chicago; U.S. Department of Energy","keywords":"NAD+ kinase; Riboside; Biochemistry; Biology; Nicotinamide mononucleotide; Nicotinamide adenine dinucleotide; Niacinamide; Nucleotide salvage; Enzyme; Nucleoside; Nicotinamide; Nucleotide; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001055842,0.0003630632,0.0002913278,0.0001495943,0.0002053085,0.0004387989,0.0003532997,0.0004695609,0.001793614],"category_scores_gemma":[0.0001743176,0.0002069721,0.000255625,0.0002182976,0.0002001649,0.0007529111,0.0001799813,0.000750604,0.0004496355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004906114,"about_ca_system_score_gemma":0.0002931092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001423375,"about_ca_topic_score_gemma":0.002813337,"domain_scores_codex":[0.9999692,0.000005161687,0.000002277249,0.000008480199,0.000009775618,0.00000504596],"domain_scores_gemma":[0.9999419,0.00001078788,0.00001786141,0.000006585727,0.00001060181,0.00001213868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001048756,0.0001170395,0.005004142,0.0005358216,0.0001280247,0.001210722,0.0005297195,0.005577351,0.9372622,0.01621899,0.001897149,0.03047024],"study_design_scores_gemma":[0.0003582227,0.001001593,0.03284976,0.00009307966,0.0004490408,0.002816176,0.0009572851,0.06304967,0.7132204,0.02079426,0.1642769,0.000133707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9589646,0.01208207,0.01568223,0.001222267,0.0001205101,0.00002472883,0.0006755421,0.0004874484,0.01074057],"genre_scores_gemma":[0.9770167,0.004696628,0.01308583,0.0001739864,0.0000211734,0.000009182419,0.001833406,0.00003316962,0.003129903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001793614,"threshold_uncertainty_score":0.00600028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03219489253724969,"score_gpt":0.3023757072726833,"score_spread":0.2701808147354335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}