{"id":"W2091580200","doi":"10.1371/journal.pbio.0050263","title":"Nicotinamide Riboside Kinase Structures Reveal New Pathways to NAD+","year":2007,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":159,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Cancer Institute; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Wellcome Trust; Ontario Genomics; Genome Canada; GlaxoSmithKline; Ontario Innovation Trust; University of Chicago; U.S. Department of Energy","keywords":"NAD+ kinase; Riboside; Biochemistry; Biology; Nicotinamide mononucleotide; Nicotinamide adenine dinucleotide; Niacinamide; Nucleotide salvage; Enzyme; Nucleoside; Nicotinamide; Nucleotide; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000286255,0.0002029023,0.0004459474,0.0001958672,0.00007019013,0.000005813263,0.0001462664,0.000235547,0.0003463643],"category_scores_gemma":[0.0005872934,0.0001376447,0.00008488826,0.0002153213,0.0001024144,0.0000168025,0.00007257521,0.0003292559,0.0001112096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007304509,"about_ca_system_score_gemma":0.0001288731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002025012,"about_ca_topic_score_gemma":0.0000828351,"domain_scores_codex":[0.9985074,0.00004034217,0.0003618154,0.0003828052,0.0001654952,0.0005420902],"domain_scores_gemma":[0.9987459,0.0001486078,0.00006741779,0.0003972529,0.00008692097,0.0005538889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006921786,0.0001308684,0.03575928,0.00005350355,0.0001355395,0.0003581648,0.0004123228,0.000002871234,0.9035549,0.003660676,0.02617239,0.02906731],"study_design_scores_gemma":[0.008483449,0.00772907,0.3858937,0.0004275923,0.000487662,0.0008769704,0.0007822203,0.00006708657,0.4145324,0.01130651,0.168521,0.0008923783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884146,0.0009381236,0.001115689,0.003828927,0.0006188328,0.0004145151,0.0000107248,0.000111184,0.004547436],"genre_scores_gemma":[0.9808667,0.00004248138,0.006697311,0.008715963,0.002165899,0.000005579696,0.00005914478,0.00002848858,0.001418427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4890225,"threshold_uncertainty_score":0.5612987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03219489253724969,"score_gpt":0.3023757072726833,"score_spread":0.2701808147354335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}