{"id":"W2091598258","doi":"10.1016/j.taap.2006.03.012","title":"The regulation of cytochrome P450 2E1 during LPS-induced inflammation in the rat","year":2006,"lang":"en","type":"article","venue":"Toxicology and Applied Pharmacology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"CYP2E1; Inflammation; Cytochrome P450; Downregulation and upregulation; Cycloheximide; Biology; Messenger RNA; Signal transduction; Pharmacology; Chemistry; Endocrinology; Internal medicine; Molecular biology; Immunology; Biochemistry; Medicine; Metabolism; Protein biosynthesis; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001874557,0.0003304205,0.0004383844,0.0002029104,0.0007348713,0.00002558875,0.0005286108,0.000508391,0.0003739624],"category_scores_gemma":[0.00002690703,0.0002366958,0.00008604235,0.0004483559,0.0006608438,0.00008832844,0.0001554671,0.0009945664,0.00003615514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005976218,"about_ca_system_score_gemma":0.00009928793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000171313,"about_ca_topic_score_gemma":0.00006785758,"domain_scores_codex":[0.9967749,0.001038989,0.000841142,0.0004313714,0.0002027905,0.0007107853],"domain_scores_gemma":[0.9979531,0.001226253,0.0004048867,0.000241414,0.00007628926,0.00009812904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008364922,0.0002133179,0.0008385411,0.00004117419,0.00007576512,0.00001217801,0.0005512459,0.001605477,0.9702955,0.01814682,0.001309776,0.006073718],"study_design_scores_gemma":[0.004679725,0.00008741779,0.1328029,0.000003825346,0.0002222383,0.00006265814,0.0001818401,0.001024084,0.8183416,0.005306105,0.03701478,0.0002727796],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855394,0.001004057,0.00001588648,0.002839006,0.0009000654,0.001211206,0.00001347299,0.00004859938,0.008428297],"genre_scores_gemma":[0.9968071,0.0005131582,0.00004340864,0.001076518,0.0008255325,0.0004241885,0.00002392652,0.00002580252,0.00026037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1519539,"threshold_uncertainty_score":0.9652176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04270959279139688,"score_gpt":0.365101832272674,"score_spread":0.3223922394812771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}