{"id":"W2091605564","doi":"10.1016/j.bmcl.2009.09.072","title":"N,N-Diethyl-4-[(3-hydroxyphenyl)(piperidin-4-yl)amino] benzamide derivatives: The development of diaryl amino piperidines as potent δ opioid receptor agonists with in vivo anti-nociceptive activity in rodent models","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Chemistry; Agonist; Opioid; Benzamide; Piperidine; Pharmacology; Analgesic; In vivo; δ-opioid receptor; Receptor; Stereochemistry; Opioid receptor; κ-opioid receptor; Functional selectivity; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000225773,0.0002662866,0.0002033961,0.0001305279,0.00009457095,0.0001103675,0.0003505166,0.0002134418,0.001964572],"category_scores_gemma":[0.0001575867,0.0001877278,0.0001051395,0.0001052717,0.0001209792,0.0002521778,0.000140072,0.0003743416,0.0005680001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001824911,"about_ca_system_score_gemma":0.0001745618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002373115,"about_ca_topic_score_gemma":0.0008315096,"domain_scores_codex":[0.9999273,0.00001172269,0.000007021005,0.00001242829,0.00001687444,0.00002463718],"domain_scores_gemma":[0.9999477,0.000006937649,0.00001883348,0.000004723189,0.000006225663,0.00001567435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004353801,0.0001116185,0.00009475405,0.0001989614,0.000005798691,0.0001667663,0.00002720817,0.0002862113,0.9841493,0.0005616563,0.0002306439,0.01373175],"study_design_scores_gemma":[0.0002785467,0.003672074,0.001949536,0.0000297423,0.00003380209,0.0008343921,0.00001977757,0.001534323,0.9807321,0.000109685,0.01078623,0.00001978419],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9492031,0.01351631,0.02307952,0.0004157688,0.0001855936,0.0002362245,0.0006138974,0.0002531449,0.01249651],"genre_scores_gemma":[0.9748818,0.007477675,0.0112023,0.0001703182,0.00004589726,0.0001129712,0.0003600383,0.00001863947,0.005730312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001964572,"threshold_uncertainty_score":0.006572127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02203613833417641,"score_gpt":0.2431778615440314,"score_spread":0.221141723209855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}