{"id":"W2091612622","doi":"10.1038/sj.neo.7900247","title":"Microarray and Biochemical Analysis of Lovastatin-induced Apoptosis of Squamous Cell Carcinomas","year":2002,"lang":"en","type":"article","venue":"Neoplasia","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Lovastatin; Mevalonate pathway; Biology; Farnesyl pyrophosphate; Apoptosis; Transcription factor; RHOA; Geranylgeranyl pyrophosphate; Cancer research; Signal transduction; Cell biology; Biochemistry; Reductase; Cholesterol; Biosynthesis; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001920192,0.0002278829,0.0005804293,0.0007384007,0.0003508678,0.0003690773,0.0002227268,0.0002856581,0.001008541],"category_scores_gemma":[0.000303962,0.0001717213,0.0004095798,0.0008743198,0.0001711564,0.000118164,0.0001458921,0.0004047044,0.0005572033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004876783,"about_ca_system_score_gemma":0.0002997738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001719696,"about_ca_topic_score_gemma":0.003022041,"domain_scores_codex":[0.9995643,0.00005385132,0.00003131238,0.0001112677,0.000149817,0.00008942075],"domain_scores_gemma":[0.9998129,0.00004928001,0.00003168927,0.00001715532,0.00006371708,0.00002525291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000171398,0.00001721249,0.0008744919,0.00005612767,0.00001081586,0.00002536768,0.00002415562,0.00006833405,0.9969257,0.00002509989,0.00006883933,0.001732533],"study_design_scores_gemma":[0.00002504556,0.0005510882,0.1542801,0.00002329274,0.0001051333,0.0004214074,0.0002051107,0.003082273,0.8284832,0.0001459374,0.0126462,0.00003117912],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9664083,0.004536919,0.01286606,0.0003001991,0.0001129889,0.0002316719,0.01091492,0.0002806624,0.004348293],"genre_scores_gemma":[0.9163576,0.004419685,0.03507328,0.0004854531,0.00007634069,0.0007182862,0.0306256,0.00009396372,0.0121497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001719696,"threshold_uncertainty_score":0.00353843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01018221826486749,"score_gpt":0.2195445239859578,"score_spread":0.2093623057210903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}