{"id":"W2091634483","doi":"10.1124/dmd.114.059352","title":"Evaluation of In Situ Generated Valproyl 1-O-β-Acyl Glucuronide in Valproic Acid Toxicity in Sandwich-Cultured Rat Hepatocytes","year":2014,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacological Effects and Toxicity Studies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Agence Nationale pour la Gestion des Déchets Radioactifs","keywords":"Toxicity; Valproic Acid; In situ; Chemistry; Glucuronide; In vitro; Hepatocyte; Metabolism; Pharmacology; Biochemistry; Biology; Epilepsy; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001933254,0.0001855548,0.0005548494,0.0002114136,0.00004378683,0.00001504852,0.00004875497,0.000100094,0.00002195912],"category_scores_gemma":[0.000392875,0.0001411618,0.00005536261,0.0003999471,0.00007234763,0.0001748526,0.00004217307,0.00019303,0.000002541188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008628881,"about_ca_system_score_gemma":0.00004428829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000214879,"about_ca_topic_score_gemma":0.0007286609,"domain_scores_codex":[0.9979927,0.0006402836,0.0004038533,0.000316067,0.0004082363,0.0002388369],"domain_scores_gemma":[0.9994817,0.00007706953,0.0001012041,0.0001140105,0.0001489451,0.00007710729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005036099,0.0006548364,0.01821975,0.0001254723,0.00003101922,0.000009040423,0.001207855,0.0002596434,0.9585139,0.000367401,0.00005938032,0.02004805],"study_design_scores_gemma":[0.006612012,0.00008958544,0.5953411,0.0001279571,0.00023045,0.000003369038,0.0001156547,0.01365549,0.3827284,0.00086356,0.00007901463,0.0001534169],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934607,0.004493501,0.0000605907,0.000448695,0.0001220993,0.0008883245,0.000007152493,0.00001932857,0.0004996169],"genre_scores_gemma":[0.9987944,0.0004111922,0.000163551,0.0003408292,0.00009009636,0.0001196624,0.000059295,0.000008983454,0.00001196729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5771214,"threshold_uncertainty_score":0.5756411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02038291377874014,"score_gpt":0.3014509748285539,"score_spread":0.2810680610498137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}