{"id":"W2091645182","doi":"10.1371/journal.pone.0003867","title":"Acute-Phase-HDL Remodeling by Heparan Sulfate Generates a Novel Lipoprotein with Exceptional Cholesterol Efflux Activity from Macrophages","year":2008,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Diabetes, Cardiovascular Risks, and Lipoproteins","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Kingston General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Cholesterol; Reverse cholesterol transport; Apolipoprotein B; Chemistry; Macrophage; Biochemistry; ABCA1; Apolipoprotein E; High-density lipoprotein; Foam cell; Heparan sulfate; Lipoprotein; Efflux; Lipid raft; Endosome; Cell biology; Glycosaminoglycan; Cell; Biology; Internal medicine; Transporter; Medicine; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001203687,0.0001949646,0.0001724857,0.0001281484,0.00007948315,0.0002574047,0.0001275312,0.0001633212,0.0002849556],"category_scores_gemma":[0.00009196951,0.0001119755,0.0002177561,0.00008063892,0.0001390089,0.0001515187,0.0001989007,0.0002370609,0.0001477787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001089902,"about_ca_system_score_gemma":0.0001007177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001255686,"about_ca_topic_score_gemma":0.0001639137,"domain_scores_codex":[0.9999396,0.00001136512,0.000005704243,0.00001095488,0.00001673245,0.00001573329],"domain_scores_gemma":[0.9999303,0.000007357228,0.00001536634,0.00001328426,0.00001006165,0.00002368193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004480177,0.000007226152,0.0003797436,0.000006501872,0.000002553387,0.00007523865,0.00000983533,0.00001412566,0.9987448,0.00004716939,0.000007755125,0.0006603506],"study_design_scores_gemma":[0.00001639604,0.0003789512,0.01201819,0.000003528718,0.00001600761,0.0009752615,0.00003461393,0.0008224702,0.9839935,0.0001367485,0.001598868,0.000005502492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974155,0.0003690043,0.001831539,0.0000292314,0.000006536467,0.00001422142,0.00004583752,0.00002093984,0.0002671537],"genre_scores_gemma":[0.9964205,0.0002467286,0.002142258,0.00004284246,0.00001245872,0.00001627114,0.0002230204,0.000009363945,0.000886511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0002849556,"threshold_uncertainty_score":0.0009533167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04952985045316022,"score_gpt":0.2411443270380494,"score_spread":0.1916144765848891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}