{"id":"W2091652935","doi":"10.1021/bi800353g","title":"Characterization of Chondroitin Sulfate Lyase ABC from <i>Bacteroides thetaiotaomicron</i> WAL2926","year":2008,"lang":"en","type":"article","venue":"Biochemistry","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Biotechnology Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Iduronic acid; Bacteroides thetaiotaomicron; Lyase; Glycosidic bond; Uronic acid; Chemistry; Active site; Dermatan sulfate; Chondroitin sulfate; Chondroitin; Biochemistry; Disaccharide; Glucuronic acid; Stereochemistry; Glycosaminoglycan; Heparan sulfate; Enzyme; Bacteroides; Polysaccharide; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009669815,0.0002233259,0.0002274739,0.0000356193,0.0001073502,0.00001739965,0.0003598227,0.0002492749,0.0001225551],"category_scores_gemma":[0.00007323812,0.0002202017,0.0001362467,0.0001132651,0.0002471408,0.000007495352,0.0001596155,0.0001322901,0.00001905115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000237227,"about_ca_system_score_gemma":0.0001864361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000971858,"about_ca_topic_score_gemma":0.000005635135,"domain_scores_codex":[0.9986423,0.00003920102,0.0002903341,0.0004790653,0.0002207383,0.0003283743],"domain_scores_gemma":[0.998938,0.00001138934,0.0001549295,0.0006207409,0.000137353,0.0001375395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001924068,0.00009711946,0.005016782,0.0000346908,0.00004984009,0.00001447982,0.00002821679,7.632603e-7,0.9931081,0.000002131532,0.0005992769,0.0008562074],"study_design_scores_gemma":[0.0006789142,0.00007651473,0.008114416,0.00002631339,0.0000105798,0.00003581421,0.00001750637,0.0000194983,0.9851963,0.00001011651,0.005577012,0.0002370166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976109,0.0003946722,0.0003402493,0.0001204574,0.00007272221,0.0001734064,0.0005586581,0.00001834177,0.0007106442],"genre_scores_gemma":[0.9938671,0.0006145202,0.0003456978,0.00009536212,0.0003435462,0.0000318049,0.002048348,0.00003463837,0.00261896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007911788,"threshold_uncertainty_score":0.8979564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01038440429642337,"score_gpt":0.2219265933204399,"score_spread":0.2115421890240165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}