{"id":"W2091652935","doi":"10.1021/bi800353g","title":"Characterization of Chondroitin Sulfate Lyase ABC from <i>Bacteroides thetaiotaomicron</i> WAL2926","year":2008,"lang":"en","type":"article","venue":"Biochemistry","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Biotechnology Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Iduronic acid; Bacteroides thetaiotaomicron; Lyase; Glycosidic bond; Uronic acid; Chemistry; Active site; Dermatan sulfate; Chondroitin sulfate; Chondroitin; Biochemistry; Disaccharide; Glucuronic acid; Stereochemistry; Glycosaminoglycan; Heparan sulfate; Enzyme; Bacteroides; Polysaccharide; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001340758,0.0003714192,0.0003252634,0.0002663933,0.0001087793,0.000326621,0.000241948,0.0002173906,0.0005913766],"category_scores_gemma":[0.0003077228,0.00009204311,0.0002537854,0.000342184,0.0001151146,0.0001405777,0.0002373024,0.0002712593,0.0006421354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000208213,"about_ca_system_score_gemma":0.0002471822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00200658,"about_ca_topic_score_gemma":0.001361287,"domain_scores_codex":[0.9998587,0.00001548872,0.00001693917,0.00003006595,0.00005961455,0.0000192184],"domain_scores_gemma":[0.9998165,0.000021497,0.00004142505,0.00001598265,0.00006125555,0.00004337199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003332907,0.00001666933,0.0005112626,0.00002268845,0.000002667008,0.00007324711,0.00001438473,0.00003860897,0.9981626,0.00002427187,0.00001939488,0.001080931],"study_design_scores_gemma":[0.00003305205,0.0004718363,0.04286287,0.00001824712,0.00004245036,0.001762534,0.0002031091,0.001774011,0.9425215,0.000101933,0.01018494,0.00002351416],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920075,0.00116184,0.003921892,0.0001300107,0.00003231723,0.00007874893,0.001323441,0.00004339425,0.001300776],"genre_scores_gemma":[0.9796724,0.0007159528,0.007496487,0.00007518417,0.00001467165,0.00005545933,0.00939795,0.00002963054,0.002542223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00200658,"threshold_uncertainty_score":0.003989816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01038440429642337,"score_gpt":0.2219265933204399,"score_spread":0.2115421890240165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}