{"id":"W2091658446","doi":"10.1016/j.yexcr.2012.04.010","title":"The Werner syndrome gene product (WRN): a repressor of hypoxia-inducible factor-1 activity","year":2012,"lang":"en","type":"article","venue":"Experimental Cell Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"Canadian Institutes of Health Research","keywords":"Biology; Repressor; Werner syndrome; Transcription factor; Molecular biology; Premature aging; Cell biology; Progeria; Reactive oxygen species; Mitochondrion; Helicase; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001617832,0.0005741072,0.0003079814,0.0002852208,0.0002057846,0.0004556839,0.0003912003,0.0003201936,0.0007336085],"category_scores_gemma":[0.0002467391,0.0002361809,0.00015618,0.0001873641,0.0005268149,0.0003153747,0.0003183608,0.0004526467,0.0004587587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004420775,"about_ca_system_score_gemma":0.0002182337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005473965,"about_ca_topic_score_gemma":0.0007700961,"domain_scores_codex":[0.9998547,0.00002191493,0.00001230081,0.00004892804,0.00004376322,0.00001848674],"domain_scores_gemma":[0.9998671,0.00002218495,0.00004419062,0.00001847269,0.000008484882,0.00003953244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000108359,0.00001017921,0.0002238889,0.00002680288,0.000004081223,0.0001864022,0.000007924094,0.00008473738,0.9970643,0.0004159221,0.00008918654,0.001778135],"study_design_scores_gemma":[0.00001649878,0.00006506025,0.002217374,0.000003822581,0.00001412148,0.001250199,0.00001463686,0.0005971707,0.9914385,0.0001795225,0.004197474,0.000005645412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9766714,0.007228075,0.0123015,0.0003941279,0.0001040717,0.00003228925,0.0004676229,0.0004365089,0.002364454],"genre_scores_gemma":[0.9877778,0.00150808,0.005511649,0.0000458574,0.00002932557,0.00002234299,0.0007587915,0.00007002215,0.004276176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007336085,"threshold_uncertainty_score":0.003207505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06315324797864891,"score_gpt":0.3626462650282561,"score_spread":0.2994930170496072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}