{"id":"W2091670726","doi":"10.1002/eji.201242999","title":"Wrestling with the repertoire: The promise and perils of next generation sequencing for antigen receptors","year":2012,"lang":"en","type":"letter","venue":"European Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"DNA sequencing; Biology; Computational biology; Repertoire; Whole genome sequencing; Protocol (science); Data science; Genome; Computer science; Genetics; DNA; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00525226,0.0008242724,0.001210662,0.0005133714,0.001288861,0.003001833,0.001450574,0.0146972,0.003170985],"category_scores_gemma":[0.01546213,0.0004801032,0.0008161996,0.0003762532,0.004407405,0.005355134,0.0008246589,0.01981002,0.003808509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002331428,"about_ca_system_score_gemma":0.00079985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005280567,"about_ca_topic_score_gemma":0.0007517017,"domain_scores_codex":[0.9967394,0.001316524,0.0002956019,0.0003966428,0.001069296,0.0001824401],"domain_scores_gemma":[0.9900074,0.007003345,0.0004033886,0.0006379473,0.001334197,0.0006136908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000682171,0.0001925047,0.003038378,0.0006860271,0.00007670099,0.01522696,0.0006377688,0.0007291443,0.01238262,0.02284351,0.7327913,0.2107128],"study_design_scores_gemma":[0.000186159,0.0003991759,0.002498256,0.0003554626,0.00005857584,0.03145661,0.0006414456,0.004406454,0.004719331,0.0653037,0.8898609,0.0001137945],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.003805268,0.02043168,0.005165884,0.9324768,0.03444891,0.00003006736,0.00005628079,0.0001767341,0.003408368],"genre_scores_gemma":[0.03996921,0.02940553,0.01109484,0.7681296,0.1410673,0.0001311462,0.0000896902,0.000111835,0.0100008],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.0146972,"threshold_uncertainty_score":0.0277769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05025013532774909,"score_gpt":0.2235974989610493,"score_spread":0.1733473636333002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}