{"id":"W2091708695","doi":"10.1523/jneurosci.1131-13.2013","title":"Effects of Adult Neural Precursor-Derived Myelination on Axonal Function in the Perinatal Congenitally Dysmyelinated Brain: Optimizing Time of Intervention, Developing Accurate Prediction Models, and Enhancing Performance","year":2013,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University Health Network","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Neuroscience; Remyelination; Subventricular zone; Neural stem cell; White matter; Oligodendrocyte; Biology; Myelin; Myelin basic protein; OLIG2; Context (archaeology); Glial fibrillary acidic protein; Stem cell; Medicine; Cell biology; Central nervous system; Immunology; Immunohistochemistry; Magnetic resonance imaging","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001751762,0.0003875509,0.0001721067,0.0001430304,0.00005586707,0.0002102168,0.0001598964,0.0001889377,0.0003625472],"category_scores_gemma":[0.0005001008,0.0001091703,0.0001561267,0.00007635319,0.0001207121,0.0001589225,0.0001389418,0.0001624299,0.00006603344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002903803,"about_ca_system_score_gemma":0.0003641047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005449758,"about_ca_topic_score_gemma":0.004235568,"domain_scores_codex":[0.9999597,0.000009704634,0.000002629565,0.000009944697,0.00001078585,0.000007271693],"domain_scores_gemma":[0.9998723,0.00006665299,0.00003001262,0.000007750881,0.00001307573,0.0000101338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000218554,0.00004595262,0.006266526,0.00007330738,0.00003548015,0.00009354552,0.00002282678,0.92246,0.04361977,0.0005660827,0.00007758725,0.02652036],"study_design_scores_gemma":[0.000002908658,0.00009252616,0.0019916,0.000003737309,0.00001128088,0.00001716928,0.000006391926,0.9852734,0.0123295,0.0001949734,0.0000734774,0.000002924646],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8851613,0.0004281578,0.1133105,0.00004507201,0.00000616509,0.00001276681,0.000115553,0.0002942273,0.0006264081],"genre_scores_gemma":[0.9931781,0.0001981604,0.006306194,0.000002997908,9.8149e-7,0.000009437318,0.00006158189,0.000009932247,0.0002325447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005449758,"threshold_uncertainty_score":0.01083612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02314619346788831,"score_gpt":0.2401350729838819,"score_spread":0.2169888795159935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}