{"id":"W2091731845","doi":"10.1021/ol9000284","title":"Synthesis of 3-Aminoisoxazoles via the Addition−Elimination of Amines on 3-Bromoisoxazolines","year":2009,"lang":"en","type":"article","venue":"Organic Letters","topic":"Fluorine in Organic Chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Yield (engineering); Combinatorial chemistry; Base (topology); Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002675986,0.0002064476,0.0002721046,0.00007855694,0.0001002398,0.000006039157,0.0004223643,0.0001770851,0.001534652],"category_scores_gemma":[0.0003918659,0.000162286,0.0001053737,0.0002845369,0.0002503171,0.00006584846,0.00003931461,0.0003494533,0.00005539639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005857421,"about_ca_system_score_gemma":0.00002665563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005597128,"about_ca_topic_score_gemma":0.000002613724,"domain_scores_codex":[0.9987243,0.0001392465,0.0004460817,0.0002261079,0.0002260443,0.0002381594],"domain_scores_gemma":[0.9982561,0.0009376183,0.0003031981,0.0003505783,0.00009405788,0.00005837312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008597769,0.0002507941,0.0003330111,0.00005116658,0.00007678922,0.000006098135,0.0002195113,0.0000523103,0.9696384,0.0002404052,0.01586654,0.01317902],"study_design_scores_gemma":[0.000409908,0.00007740225,0.008101887,0.00003262878,0.0001447533,0.00002269199,0.00007301142,0.0001462411,0.9894639,0.0001473352,0.001228572,0.0001516867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748379,0.00007525413,0.00009525569,0.02361728,0.0003390149,0.0001763021,0.00005600855,0.00005676031,0.0007462066],"genre_scores_gemma":[0.995745,0.00006739086,0.00008920669,0.003578254,0.0003652984,0.00001135182,0.00002222482,0.00002225417,0.00009900021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0209071,"threshold_uncertainty_score":0.9993781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0345952682957857,"score_gpt":0.3358205467304582,"score_spread":0.3012252784346726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}