{"id":"W2091752803","doi":"10.1016/s0002-9440(10)61747-6","title":"Anorectal Malformations Caused by Defects in Sonic Hedgehog Signaling","year":2001,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":222,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health; Heart and Stroke Foundation of Canada","keywords":"Sonic hedgehog; Hedgehog signaling pathway; Hedgehog; Cell biology; Signal transduction; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000178227,0.0007272165,0.0003638274,0.001373527,0.0004330121,0.0003563603,0.0004117025,0.0006163597,0.004027253],"category_scores_gemma":[0.0004240618,0.0005523702,0.0003333868,0.0003940257,0.001128638,0.0005169092,0.0005941035,0.00124989,0.0006319183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000417162,"about_ca_system_score_gemma":0.0003418814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001260675,"about_ca_topic_score_gemma":0.001630282,"domain_scores_codex":[0.9997767,0.00004482787,0.0000274759,0.00004595681,0.00004895932,0.00005603063],"domain_scores_gemma":[0.9994885,0.0001532212,0.000151155,0.00005964041,0.00002314761,0.0001242757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009248457,0.0001039235,0.001524442,0.00006963859,0.00003762604,0.006215922,0.0000557919,0.0002419933,0.9868348,0.001554001,0.0001927173,0.002244243],"study_design_scores_gemma":[0.000128503,0.0005260565,0.02193284,0.00001700318,0.00009653613,0.01935062,0.0001324664,0.0009242917,0.9523238,0.0002939984,0.004253544,0.00002045857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990312,0.001440285,0.002362164,0.000206546,0.00006763839,0.00005251477,0.000633723,0.0001454784,0.004779691],"genre_scores_gemma":[0.9928542,0.0007972341,0.001723584,0.00004811285,0.00001667636,0.00003894593,0.0003224095,0.00004935227,0.004149487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004027253,"threshold_uncertainty_score":0.0134725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009220811843783932,"score_gpt":0.2531806213981736,"score_spread":0.2439598095543897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}