{"id":"W2091796431","doi":"10.1016/j.cell.2014.03.040","title":"A Chromatin-Dependent Role of the Fragile X Mental Retardation Protein FMRP in the DNA Damage Response","year":2014,"lang":"en","type":"article","venue":"Cell","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":182,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute of General Medical Sciences; National Institute of Mental Health; National Institute on Aging; National Cancer Institute; National Institutes of Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Howard Hughes Medical Institute; U.S. Public Health Service; Wellcome Trust","keywords":"Biology; Chromatin; Genetics; Fragile X syndrome; Cell biology; FMR1; Histone; Translation (biology); Polycomb-group proteins; DNA repair; DNA; Fragile x; Gene; Gene expression; Messenger RNA; Repressor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001871186,0.0003473985,0.000184313,0.0002271443,0.0003190566,0.0004159743,0.0003178859,0.0005829592,0.00132444],"category_scores_gemma":[0.0002282047,0.0001812402,0.0002495083,0.000120032,0.0005916068,0.0004483474,0.0003487156,0.0005510067,0.0005073521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003265609,"about_ca_system_score_gemma":0.0001624823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004519243,"about_ca_topic_score_gemma":0.0006295656,"domain_scores_codex":[0.9999106,0.00001402564,0.00000532398,0.00002542949,0.00002329712,0.00002136327],"domain_scores_gemma":[0.9998448,0.00003526231,0.00003530615,0.00002958665,0.00001558756,0.00003947222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001570647,0.0000212054,0.0003109876,0.00004184222,0.000007332751,0.0002935973,0.00001870506,0.0001055471,0.9954295,0.00113018,0.0001348281,0.002349024],"study_design_scores_gemma":[0.0000609616,0.0002932292,0.03187479,0.00002156884,0.00002530578,0.001767341,0.00006564584,0.001422526,0.9558194,0.001489092,0.007139195,0.00002086786],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9665618,0.01582477,0.009485178,0.000983236,0.0001552349,0.00002893036,0.0004439569,0.0002744041,0.00624251],"genre_scores_gemma":[0.9939658,0.001633995,0.001896405,0.0001201268,0.00003678431,0.000009429943,0.0002958196,0.00001545948,0.002026294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00132444,"threshold_uncertainty_score":0.004430711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003879713747084415,"score_gpt":0.1912545879441892,"score_spread":0.1873748741971048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}