{"id":"W2091796431","doi":"10.1016/j.cell.2014.03.040","title":"A Chromatin-Dependent Role of the Fragile X Mental Retardation Protein FMRP in the DNA Damage Response","year":2014,"lang":"en","type":"article","venue":"Cell","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":182,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute of General Medical Sciences; National Institute of Mental Health; National Institute on Aging; National Cancer Institute; National Institutes of Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Howard Hughes Medical Institute; U.S. Public Health Service; Wellcome Trust","keywords":"Biology; Chromatin; Genetics; Fragile X syndrome; Cell biology; FMR1; Histone; Translation (biology); Polycomb-group proteins; DNA repair; DNA; Fragile x; Gene; Gene expression; Messenger RNA; Repressor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003112184,0.00007259096,0.00005279316,0.00001422187,0.00004748867,0.000009760874,0.0002455698,0.00004476403,0.00001482692],"category_scores_gemma":[0.0000374535,0.00004776855,0.00003693281,0.00005475851,0.00003976436,0.000001362333,0.000097643,0.00005333773,0.000006265876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005884609,"about_ca_system_score_gemma":0.0000282992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001164742,"about_ca_topic_score_gemma":0.00003753887,"domain_scores_codex":[0.9992887,0.0002126077,0.0001262028,0.0001465491,0.0001240264,0.0001018893],"domain_scores_gemma":[0.9996253,0.000008338229,0.00005836591,0.0002812644,0.00001262883,0.00001409486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000616016,0.00005979996,0.0003949706,0.000006970673,0.000002150035,1.46772e-7,0.0003266393,0.0000144955,0.9986835,0.000007400632,0.00021893,0.0002233754],"study_design_scores_gemma":[0.0003422662,0.0001107284,0.06087882,0.000006833256,0.000002528641,0.000001009863,0.0003523174,0.0000739266,0.9292246,0.00007855642,0.008867984,0.00006042028],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964597,0.00006761743,0.00001155822,0.0002242143,0.00003617843,0.0003137409,0.000006859946,0.000001776577,0.002878329],"genre_scores_gemma":[0.9992576,0.000009322995,0.00007785796,0.0001944414,0.000007894439,0.00002551959,0.00002243232,0.000008443226,0.0003965426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06945891,"threshold_uncertainty_score":0.1947945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003879713747084415,"score_gpt":0.1912545879441892,"score_spread":0.1873748741971048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}