{"id":"W2091805392","doi":"10.1021/bi701494m","title":"Effects of Metal-Binding Loop Mutations on Ligand Binding to Calcium- and Integrin-Binding Protein 1. Evolution of the EF-Hand?","year":2008,"lang":"en","type":"article","venue":"Biochemistry","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Chemistry; EF hand; Mutant; Binding site; Binding domain; Biophysics; Ligand (biochemistry); Divalent; Calcium-binding protein; Calcium; Crystallography; Biochemistry; Biology; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002769275,0.0006594525,0.0003394607,0.000203198,0.0002215993,0.0003312385,0.0005193967,0.0006517982,0.00120014],"category_scores_gemma":[0.0004675145,0.0002422366,0.0003098657,0.0001948921,0.0004181786,0.000190303,0.0003646537,0.0005448148,0.0003921019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005308457,"about_ca_system_score_gemma":0.0002456153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002039828,"about_ca_topic_score_gemma":0.001611335,"domain_scores_codex":[0.9996352,0.0001028599,0.00005735682,0.00005785256,0.00008378542,0.00006292497],"domain_scores_gemma":[0.9996206,0.0001568166,0.00009590528,0.00002210043,0.00002907231,0.00007547114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009247012,0.0002491574,0.0006046912,0.00006620728,0.0000399738,0.0004379395,0.00004708058,0.0008143756,0.994406,0.0002323727,0.00007970845,0.002097795],"study_design_scores_gemma":[0.0001404184,0.0007489359,0.003292907,0.00002321671,0.00006440334,0.0009742107,0.00005780268,0.004720811,0.9874423,0.00009032755,0.002419732,0.00002487542],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984846,0.0003172538,0.0004026706,0.00004731273,0.00001840673,0.00002167875,0.00009178673,0.00002040905,0.0005959275],"genre_scores_gemma":[0.9981455,0.0001582059,0.0008310381,0.00006562317,0.000007714087,0.00001357787,0.0001833746,0.00004124668,0.0005537121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002039828,"threshold_uncertainty_score":0.004055977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0198597616844334,"score_gpt":0.2879315923842062,"score_spread":0.2680718306997728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}