{"id":"W2091826524","doi":"10.1210/me.2004-0182","title":"Pituitary Tumor-Derived Fibroblast Growth Factor Receptor 4 Isoform Disrupts Neural Cell-Adhesion Molecule/N-Cadherin Signaling to Diminish Cell Adhesiveness: A Mechanism Underlying Pituitary Neoplasia","year":2004,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Mount Sinai Hospital","funders":"","keywords":"Biology; Neural cell adhesion molecule; Cadherin; Cell adhesion molecule; Mechanism (biology); Cell adhesion; Cell biology; Gene isoform; Receptor; Adhesion; Cancer research; Cell; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001532216,0.0004834303,0.0002504006,0.0002219945,0.0001624,0.0002687231,0.0002823876,0.000289549,0.000716553],"category_scores_gemma":[0.0001119008,0.0001642528,0.0003518447,0.0001223483,0.0002749932,0.0002018015,0.0001768249,0.0005112496,0.0002369014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004462281,"about_ca_system_score_gemma":0.0002926552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00156176,"about_ca_topic_score_gemma":0.002460462,"domain_scores_codex":[0.9998465,0.00002542955,0.00001427492,0.00002765105,0.00004898235,0.00003719891],"domain_scores_gemma":[0.9999257,0.00001412055,0.0000261928,0.000008092776,0.000006361501,0.00001952204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002418718,0.000007083281,0.00006107274,0.00001217881,0.000002158792,0.00005041979,0.000004589712,0.0000191839,0.9994999,0.00004225413,0.000009679989,0.0002673152],"study_design_scores_gemma":[0.00002472352,0.0002460034,0.003456647,0.00000289632,0.00001700738,0.0007260398,0.00003006779,0.0006390865,0.9928238,0.00003953784,0.001988799,0.00000524669],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944147,0.001437395,0.002578245,0.0001557872,0.00002628514,0.00003734268,0.0002625401,0.00007093346,0.00101678],"genre_scores_gemma":[0.9944101,0.001038415,0.00203109,0.00005300809,0.000007937731,0.00003981603,0.0003151602,0.00001625424,0.002088243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00156176,"threshold_uncertainty_score":0.003237665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01728975966877415,"score_gpt":0.2605787583104285,"score_spread":0.2432889986416544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}