{"id":"W2091826524","doi":"10.1210/me.2004-0182","title":"Pituitary Tumor-Derived Fibroblast Growth Factor Receptor 4 Isoform Disrupts Neural Cell-Adhesion Molecule/N-Cadherin Signaling to Diminish Cell Adhesiveness: A Mechanism Underlying Pituitary Neoplasia","year":2004,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Mount Sinai Hospital","funders":"","keywords":"Biology; Neural cell adhesion molecule; Cadherin; Cell adhesion molecule; Mechanism (biology); Cell adhesion; Cell biology; Gene isoform; Receptor; Adhesion; Cancer research; Cell; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001315114,0.00102316,0.0007597085,0.0004606592,0.0003935874,0.0001282525,0.001246198,0.0004580547,0.0001862028],"category_scores_gemma":[0.000187548,0.001114234,0.0004920859,0.0005078341,0.0002363171,0.00005158484,0.00126698,0.0007710796,0.0003845675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002579911,"about_ca_system_score_gemma":0.000336366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002336253,"about_ca_topic_score_gemma":0.00005023163,"domain_scores_codex":[0.9938986,0.0003919223,0.0008396045,0.001888116,0.0007097605,0.002271968],"domain_scores_gemma":[0.9975236,0.000063657,0.000262036,0.001120533,0.0002925837,0.0007375893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004393178,0.0002880046,0.0002111223,0.000248223,0.0001058203,0.0008797895,0.0002869235,0.001006217,0.9959599,0.0002431706,0.0001390145,0.0001924403],"study_design_scores_gemma":[0.002520353,0.003059407,0.0008949551,0.0001084207,0.00004209081,0.0002460831,0.0004635642,0.00003204913,0.9907234,0.0004319224,0.0003514048,0.001126386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799672,0.0004013983,0.01641309,0.0005559811,0.0003834471,0.001573435,0.0001257033,0.0001747817,0.0004049381],"genre_scores_gemma":[0.9922389,0.00007465376,0.005257867,0.001187797,0.0001667564,0.0003490137,0.0003229024,0.000285589,0.0001165507],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01227164,"threshold_uncertainty_score":0.9991308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01728975966877415,"score_gpt":0.2605787583104285,"score_spread":0.2432889986416544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}