{"id":"W2091831292","doi":"10.1016/j.str.2008.10.018","title":"Structure of the Pseudokinase VRK3 Reveals a Degraded Catalytic Site, a Highly Conserved Kinase Fold, and a Putative Regulatory Binding Site","year":2009,"lang":"en","type":"article","venue":"Structure","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":196,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; VINNOVA; Stiftelsen för Strategisk Forskning; Canadian Institutes of Health Research; Genome Canada; Ontario Innovation Trust; Wellcome Trust; National Human Genome Research Institute; GlaxoSmithKline","keywords":"Active site; Conserved sequence; Biology; Structural similarity; Binding site; Kinase; Biochemistry; Protein structure; Cell biology; Residue (chemistry); Enzyme; Plasma protein binding; Peptide sequence; Biophysics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007176131,0.0003443254,0.0003212616,0.0001533241,0.0002441609,0.0005540617,0.0003365672,0.00049204,0.001069859],"category_scores_gemma":[0.0001858738,0.0001521395,0.0004670744,0.0003031103,0.0003209435,0.0002793526,0.0001852354,0.000873386,0.0004350361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006681249,"about_ca_system_score_gemma":0.0003913224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002109183,"about_ca_topic_score_gemma":0.001552194,"domain_scores_codex":[0.9999411,0.000005673631,0.000003467097,0.00001584842,0.00002097354,0.00001293577],"domain_scores_gemma":[0.999897,0.00001283732,0.00003381141,0.000009030002,0.00001423612,0.00003302805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008436873,0.00004426017,0.003150166,0.0002109256,0.00004510537,0.001681805,0.0001771314,0.002378711,0.9817322,0.001261925,0.000808408,0.007665775],"study_design_scores_gemma":[0.0003499085,0.001169987,0.176796,0.0001106184,0.0003062841,0.0317198,0.0008638458,0.04865729,0.6751955,0.005480605,0.05905272,0.0002975391],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910335,0.001905306,0.003675613,0.0003939217,0.00006994862,0.00001102763,0.001087285,0.0001564496,0.00166696],"genre_scores_gemma":[0.9906694,0.0007727482,0.0037694,0.0001393172,0.00001572336,0.00000690711,0.003193459,0.00003711213,0.001395861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002109183,"threshold_uncertainty_score":0.004847586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004461116689184315,"score_gpt":0.2189860568221906,"score_spread":0.2145249401330062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}