{"id":"W2091831292","doi":"10.1016/j.str.2008.10.018","title":"Structure of the Pseudokinase VRK3 Reveals a Degraded Catalytic Site, a Highly Conserved Kinase Fold, and a Putative Regulatory Binding Site","year":2009,"lang":"en","type":"article","venue":"Structure","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":196,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; VINNOVA; Stiftelsen för Strategisk Forskning; Canadian Institutes of Health Research; Genome Canada; Ontario Innovation Trust; Wellcome Trust; National Human Genome Research Institute; GlaxoSmithKline","keywords":"Active site; Conserved sequence; Biology; Structural similarity; Binding site; Kinase; Biochemistry; Protein structure; Cell biology; Residue (chemistry); Enzyme; Plasma protein binding; Peptide sequence; Biophysics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004534682,0.0002884594,0.0002825988,0.00005394666,0.0001464953,0.00003477526,0.0002041495,0.0002268356,0.00001250189],"category_scores_gemma":[0.0001555095,0.0002014585,0.0001402775,0.0001837846,0.0002368055,0.000009085824,0.0001088677,0.0001732309,6.481841e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001883923,"about_ca_system_score_gemma":0.00010353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002950738,"about_ca_topic_score_gemma":0.00004546712,"domain_scores_codex":[0.9986608,0.0001031558,0.0002759692,0.0004608243,0.000208676,0.0002905566],"domain_scores_gemma":[0.9989195,0.00002220073,0.0002345798,0.0005612133,0.00009854156,0.0001640052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001454892,0.00001781158,0.01700872,0.00007353335,0.00005289703,0.00001820244,0.0002323,0.00004229857,0.9808639,0.0002298381,0.0009592319,0.0003558068],"study_design_scores_gemma":[0.001695754,0.0002235867,0.167357,0.00009994789,0.0001648167,0.0001067592,0.0001460803,0.00004987812,0.8270054,0.002524431,0.0002517381,0.000374576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962461,0.001384759,0.000007656291,0.0002349856,0.00009892777,0.0003472742,0.001592682,0.00001279147,0.00007481388],"genre_scores_gemma":[0.9986429,0.00003324412,0.0003080596,0.000399491,0.00008684305,0.000002984322,0.0003440335,0.00002041702,0.0001620098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1538585,"threshold_uncertainty_score":0.8215237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004461116689184315,"score_gpt":0.2189860568221906,"score_spread":0.2145249401330062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}