{"id":"W2091844909","doi":"10.1016/j.pain.2006.09.033","title":"Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways","year":2006,"lang":"en","type":"article","venue":"Pain","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cegep de Sept Iles","funders":"National Institute on Drug Abuse","keywords":"Nociception; Hyperalgesia; Rostral ventromedial medulla; Nociceptor; Morphine; Opioid; Medicine; Neuroscience; Spinal cord; Pharmacology; Receptor; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004112516,0.0003253173,0.0002780188,0.00009175768,0.0001153764,0.0001738129,0.000117709,0.0001887877,0.001623206],"category_scores_gemma":[0.00008515376,0.00009354846,0.0001092939,0.00007050818,0.0002127364,0.0001710842,0.0001407696,0.0003250418,0.0003018985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002115841,"about_ca_system_score_gemma":0.0001586113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007571316,"about_ca_topic_score_gemma":0.001036702,"domain_scores_codex":[0.9999452,0.000006454255,0.000006474519,0.00001047078,0.00001570582,0.00001579199],"domain_scores_gemma":[0.9999646,0.000002575067,0.00001741686,0.000002348663,0.00000464814,0.000008391839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001530725,0.00001891051,0.0005520976,0.0001392844,0.00000680442,0.00008858449,0.00002246252,0.0000421129,0.9930516,0.000107511,0.0000435741,0.005773981],"study_design_scores_gemma":[0.00009368932,0.002586566,0.1529711,0.00009849167,0.0001615882,0.003818238,0.0002295282,0.001423936,0.8294591,0.0004865472,0.008649783,0.00002133099],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876002,0.00809608,0.002213533,0.0001350363,0.00003090821,0.00002820913,0.0001405748,0.00005700591,0.001698378],"genre_scores_gemma":[0.9920785,0.00498369,0.0009646786,0.00005637391,0.0000153367,0.00001832336,0.0001073947,0.000004096882,0.001771622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001623206,"threshold_uncertainty_score":0.005430162,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02418897535965383,"score_gpt":0.2548152086370072,"score_spread":0.2306262332773533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}