{"id":"W2091880370","doi":"10.1038/jcbfm.2013.160","title":"Brain Bioavailability of Human Intravenous Immunoglobulin and its Transport through the Murine Blood–Brain Barrier","year":2013,"lang":"en","type":"article","venue":"Journal of Cerebral Blood Flow & Metabolism","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":190,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval; Centre hospitalier universitaire de Québec; Héma-Québec","funders":"Canadian Institutes of Health Research; Grifols","keywords":"Blood–brain barrier; Bioavailability; Central nervous system; Pharmacokinetics; Medicine; Pharmacology; Perfusion; Immunostaining; Cerebral cortex; Antibody; Pathology; Immunology; Internal medicine; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003006379,0.0002525325,0.0001976136,0.0002245957,0.00006630603,0.000337395,0.0001483354,0.0002294995,0.000709709],"category_scores_gemma":[0.0002725186,0.00006043017,0.0001014367,0.00009277274,0.0001997226,0.000217932,0.00007578239,0.0003151249,0.0002050759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003431227,"about_ca_system_score_gemma":0.0003056125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001722088,"about_ca_topic_score_gemma":0.0007728297,"domain_scores_codex":[0.9998686,0.00003770509,0.000006193643,0.00002713165,0.00003467813,0.00002567409],"domain_scores_gemma":[0.9998707,0.00003348559,0.00004040813,0.00001575067,0.00002593218,0.00001374778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004370396,0.0000347552,0.0005028796,0.00004811028,0.00001166463,0.00003618997,0.00003523702,0.0001216962,0.9923655,0.0001670365,0.00007321285,0.006166575],"study_design_scores_gemma":[0.00003353369,0.001614154,0.009041352,0.00001922336,0.00004456257,0.0002816565,0.00003620625,0.002624289,0.9827381,0.0002023811,0.003355066,0.000009605867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855264,0.005830219,0.007203557,0.00009753068,0.00001305181,0.00002833128,0.0002296974,0.00008427145,0.0009870081],"genre_scores_gemma":[0.9942087,0.00159857,0.002448797,0.0000303889,0.0000103672,0.00002619964,0.000305779,0.00001865413,0.001352575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001722088,"threshold_uncertainty_score":0.003424168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01144516294869163,"score_gpt":0.2407363033689346,"score_spread":0.229291140420243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}