{"id":"W2091910695","doi":"10.1016/s0378-1119(02)01074-0","title":"An L1 element disrupts human bone sialoprotein promoter: lack of tissue-specific regulation by distalless5 (Dlx5) and runt homeodomain protein2 (Runx2)/core binding factor a1 (Cbfa1) elements","year":2002,"lang":"en","type":"article","venue":"Gene","topic":"Bone and Dental Protein Studies","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Biology; Promoter; Molecular biology; Bone sialoprotein; Transcription factor; Homeobox; Response element; Transcription (linguistics); Enhancer; DLX5; Gene; EMX2; Genetics; Gene expression; Osteocalcin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002477407,0.0004877058,0.0003048091,0.0004112894,0.0003140775,0.0003237138,0.0005603186,0.0006381743,0.003334605],"category_scores_gemma":[0.0002548317,0.0003974961,0.0005092934,0.0001861855,0.000786089,0.0002186311,0.0003979814,0.0008219429,0.0009778403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006045152,"about_ca_system_score_gemma":0.000451935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002847398,"about_ca_topic_score_gemma":0.00352823,"domain_scores_codex":[0.9996064,0.00009477033,0.0000577942,0.0000915057,0.00007135632,0.00007812624],"domain_scores_gemma":[0.9995907,0.0001442051,0.00009375456,0.00004970632,0.00001968671,0.0001019199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000235708,0.00006378759,0.000185477,0.00001916725,0.000009973271,0.0001190797,0.00002397186,0.0001110533,0.9984993,0.0002947573,0.00003456207,0.0004032547],"study_design_scores_gemma":[0.00005192731,0.0002029087,0.002189561,0.000008455721,0.00002533287,0.0006414778,0.00005549141,0.001380231,0.9937537,0.00008927825,0.001594563,0.000007155666],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949125,0.0004618931,0.002872334,0.0001506165,0.00004211286,0.00002958376,0.0004027754,0.00009121439,0.00103697],"genre_scores_gemma":[0.9961217,0.0001339191,0.001253482,0.00006786943,0.00001107609,0.00001994543,0.0006050902,0.00007363609,0.001713243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003334605,"threshold_uncertainty_score":0.01115537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07136089687667505,"score_gpt":0.322520104389487,"score_spread":0.251159207512812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}