{"id":"W2091910695","doi":"10.1016/s0378-1119(02)01074-0","title":"An L1 element disrupts human bone sialoprotein promoter: lack of tissue-specific regulation by distalless5 (Dlx5) and runt homeodomain protein2 (Runx2)/core binding factor a1 (Cbfa1) elements","year":2002,"lang":"en","type":"article","venue":"Gene","topic":"Bone and Dental Protein Studies","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Biology; Promoter; Molecular biology; Bone sialoprotein; Transcription factor; Homeobox; Response element; Transcription (linguistics); Enhancer; DLX5; Gene; EMX2; Genetics; Gene expression; Osteocalcin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002784888,0.0003571347,0.0006193969,0.0001473444,0.0002980733,0.00004653661,0.0001110552,0.0001279728,0.0005128195],"category_scores_gemma":[0.00001608028,0.0003128022,0.00007687847,0.0002165115,0.0001701382,0.000175981,0.0001424967,0.0001710426,0.00003421963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001333999,"about_ca_system_score_gemma":0.000009757607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007192107,"about_ca_topic_score_gemma":0.0000354482,"domain_scores_codex":[0.997418,0.00006473657,0.0007851421,0.0006044167,0.000648147,0.0004795344],"domain_scores_gemma":[0.9988102,0.00001132601,0.0003497604,0.0005217897,0.00008832802,0.0002186122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001517119,0.0006340456,0.005069663,0.0002941297,0.00009736531,0.0000413873,0.001008585,4.735068e-7,0.9632497,0.00008471924,0.001277413,0.02809079],"study_design_scores_gemma":[0.007047032,0.003627586,0.04993984,0.0004631076,0.0001362488,0.00005233208,0.0007409586,0.0001567151,0.9171443,0.0004359396,0.01945304,0.000802875],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925066,0.002930111,0.0003211984,0.0003491045,0.0000597437,0.003277669,0.0001603044,0.00008021429,0.0003150786],"genre_scores_gemma":[0.9949089,0.000292054,0.002123225,0.00004300548,0.0001891085,0.0002363342,0.0002820393,0.00005983239,0.001865484],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0461054,"threshold_uncertainty_score":0.9999324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07136089687667505,"score_gpt":0.322520104389487,"score_spread":0.251159207512812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}