{"id":"W2091953759","doi":"10.1021/bi801276h","title":"Crystal Structures of Human Δ4-3-Ketosteroid 5β-Reductase (AKR1D1) Reveal the Presence of an Alternative Binding Site Responsible for Substrate Inhibition<sup>,</sup>","year":2008,"lang":"en","type":"article","venue":"Biochemistry","topic":"Aldose Reductase and Taurine","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Ketosteroid; Binding site; Substrate (aquarium); Chemistry; Crystal (programming language); Substrate specificity; Active site; Crystallography; Stereochemistry; Enzyme; Biochemistry; Biology; Ecology; Isomerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000203715,0.0005543644,0.0004073478,0.0001587871,0.0002092333,0.0007020941,0.0004943631,0.0003999513,0.001918952],"category_scores_gemma":[0.0003255299,0.0003028671,0.000275824,0.000391307,0.0001825101,0.0003258059,0.0002288209,0.0007429935,0.0009180842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007166995,"about_ca_system_score_gemma":0.0002638451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002357432,"about_ca_topic_score_gemma":0.00294185,"domain_scores_codex":[0.9998916,0.00001489711,0.000008682382,0.00003069594,0.00003885804,0.00001519467],"domain_scores_gemma":[0.9998442,0.00003012326,0.00005441348,0.0000103605,0.00002664571,0.00003418025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001556672,0.0002580165,0.0134033,0.0009737861,0.0002380505,0.0008981912,0.000501826,0.002262152,0.9344795,0.002896973,0.008771437,0.03376009],"study_design_scores_gemma":[0.0005608625,0.0008549106,0.09950553,0.0001397341,0.0006476586,0.008127876,0.001104984,0.01964792,0.7045424,0.002270406,0.162444,0.0001537353],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9600558,0.02467774,0.005038073,0.0009492875,0.0001625609,0.00003772151,0.00328911,0.0003676849,0.005421959],"genre_scores_gemma":[0.9607126,0.008311201,0.01174611,0.000383643,0.00003704823,0.00002559163,0.01278138,0.00004644661,0.005956007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002357432,"threshold_uncertainty_score":0.00641948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01884209302738668,"score_gpt":0.2738427155464614,"score_spread":0.2550006225190747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}