{"id":"W2091954884","doi":"10.1111/j.1476-5381.2010.00916.x","title":"The calmodulin inhibitor<i>N</i>‐(6‐aminohexyl)‐5‐chloro‐1‐naphthalene sulphonamide directly blocks human ether<i>à</i>‐go‐go‐related gene potassium channels stably expressed in human embryonic kidney 293 cells","year":2010,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"hERG; Calmodulin; HEK 293 cells; Potassium channel; Chemistry; Depolarization; Patch clamp; Potassium channel blocker; Ion channel; Biophysics; Biochemistry; Biology; Gene; Enzyme; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001189818,0.0003616098,0.0005005838,0.000169799,0.0004648042,0.00009359941,0.0006751539,0.0005900974,0.0002874538],"category_scores_gemma":[0.00003779061,0.0003649424,0.0003190362,0.0002278401,0.0003594768,0.00003416689,0.0001002885,0.001182338,0.000006677666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005389682,"about_ca_system_score_gemma":0.0002492284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001306102,"about_ca_topic_score_gemma":0.0004318594,"domain_scores_codex":[0.9969606,0.0003091553,0.001121367,0.0004917989,0.0003734777,0.0007435696],"domain_scores_gemma":[0.9983277,0.00005088586,0.0006884796,0.0002245336,0.0003667897,0.0003415944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000221743,0.0003298434,0.0003572253,0.00002459625,0.000190573,0.0005083463,0.0001218387,0.000403014,0.9837824,0.000009068071,0.01301807,0.001033299],"study_design_scores_gemma":[0.004275424,0.0004003632,0.002439719,0.00006715773,0.0001206014,0.0009570705,0.00004862008,0.00006177459,0.9689586,0.000186992,0.02208656,0.0003971403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929698,0.001733587,0.0000541743,0.0006075481,0.003905751,0.0003704499,0.00009542522,0.00001997136,0.0002433491],"genre_scores_gemma":[0.9941975,0.0009221197,0.00008916591,0.0003662374,0.001983885,0.00003226405,0.0002038583,0.00007737269,0.002127549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01482381,"threshold_uncertainty_score":0.9998803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006411414205182113,"score_gpt":0.2489307869533511,"score_spread":0.242519372748169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}