{"id":"W2091961739","doi":"10.1038/nrc1431","title":"BRCA1 and BRCA2: 1994 and beyond","year":2004,"lang":"en","type":"review","venue":"Nature reviews. Cancer","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":968,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Coalition for Research in Women's Health; Women's College Hospital; Sunnybrook Health Science Centre","funders":"","keywords":"Breast cancer; BRCA2 Protein; Medicine; Epidemiology; Cancer; Ethnic group; Genetic epidemiology; Oncology; Biology; Genetics; Bioinformatics; Mutation; Gene; Germline mutation; Internal medicine; Political science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008554991,0.001173668,0.001633098,0.001810525,0.0004852714,0.001656323,0.001636649,0.002305751,0.005222949],"category_scores_gemma":[0.001117187,0.0005215535,0.0004519493,0.002744217,0.001185604,0.00323013,0.001153194,0.003122952,0.004180509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001528398,"about_ca_system_score_gemma":0.001472074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002289439,"about_ca_topic_score_gemma":0.003731288,"domain_scores_codex":[0.9997817,0.00003734275,0.00001972317,0.00003105771,0.0001013395,0.00002897709],"domain_scores_gemma":[0.9995346,0.0001938019,0.00003958424,0.00001831938,0.0001357958,0.00007786253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002083364,0.00004997366,0.0002316706,0.006661847,0.00005395409,0.0004085469,0.0001261955,0.0005660963,0.002609495,0.01218084,0.1507607,0.8261423],"study_design_scores_gemma":[0.00001569488,0.00002768195,0.0004519846,0.00104919,0.00002567272,0.0007729309,0.00006099012,0.00004177546,0.0001858775,0.004434727,0.9929233,0.00001014689],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006322277,0.9973059,0.0001201537,0.0008441033,0.0004632898,0.000002290737,0.000009420619,0.000006508846,0.001185122],"genre_scores_gemma":[0.0004667497,0.9972107,0.0001256278,0.0005536546,0.0003338277,0.000005018697,0.0000188238,0.000001596055,0.001284058],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005222949,"threshold_uncertainty_score":0.01747251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01909578626634546,"score_gpt":0.3629400555944491,"score_spread":0.3438442693281037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}