{"id":"W2092000382","doi":"10.1289/ehp.1002409","title":"Exploring Indirect Sources of Human Exposure to Perfluoroalkyl Carboxylates (PFCAs): Evaluating Uptake, Elimination, and Biotransformation of Polyfluoroalkyl Phosphate Esters (PAPs) in the Rat","year":2010,"lang":"en","type":"article","venue":"Environmental Health Perspectives","topic":"Per- and polyfluoroalkyl substances research","field":"Environmental Science","cited_by":188,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Biotransformation; Chemistry; Bioavailability; Perfluorooctanoic acid; Phosphate; Pharmacokinetics; Metabolism; Urine; Environmental chemistry; Biochemistry; Chromatography; Enzyme; Pharmacology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004386611,0.0008263289,0.0002631016,0.0002934126,0.0001700448,0.0002794346,0.0002273377,0.0005264229,0.001962241],"category_scores_gemma":[0.0003356822,0.0001904458,0.0004375152,0.0001606717,0.0003586462,0.0003876693,0.0001712608,0.0006117874,0.0006521303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000380546,"about_ca_system_score_gemma":0.0004779755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001919734,"about_ca_topic_score_gemma":0.001762146,"domain_scores_codex":[0.9997967,0.00004075545,0.000006979854,0.00006278168,0.00005042254,0.00004229728],"domain_scores_gemma":[0.999763,0.0000434911,0.00007864931,0.00002842582,0.00005047838,0.00003588884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004277392,0.0007425259,0.01817449,0.0002290586,0.0001108208,0.0002284201,0.0001255097,0.000705068,0.9479511,0.0001630948,0.0001846956,0.02710777],"study_design_scores_gemma":[0.00006772741,0.0205713,0.02333871,0.0000183628,0.0002122842,0.0006461967,0.0001418748,0.002411076,0.9505609,0.0001468186,0.001861575,0.00002320914],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906268,0.001568544,0.006279934,0.00007883425,0.00002157316,0.00008919556,0.0003209847,0.00005345141,0.0009607193],"genre_scores_gemma":[0.9887473,0.002275566,0.005325448,0.00009980826,0.00002232931,0.0001306608,0.0004392033,0.00002776173,0.002932002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001962241,"threshold_uncertainty_score":0.006564379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.057099827726716,"score_gpt":0.3235187154780019,"score_spread":0.2664188877512859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}