{"id":"W2092002882","doi":"10.1021/bi300065z","title":"Role of the Juxtamembrane Region of Cytoplasmic Loop 3 in the Gating and Conductance of the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel","year":2012,"lang":"en","type":"article","venue":"Biochemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"Cystic fibrosis transmembrane conductance regulator; Gating; Chloride channel; Cytoplasm; Biophysics; Transmembrane protein; Conductance; Chemistry; Transmembrane domain; Loop (graph theory); Biochemistry; Membrane; Biology; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001906706,0.0001885782,0.0002136091,0.00009852164,0.0001628111,0.00026972,0.0002709319,0.0005313896,0.0004269677],"category_scores_gemma":[0.0004043336,0.0000975803,0.0002576733,0.00009031199,0.0004137641,0.0004050165,0.0002604428,0.0002956086,0.0001604154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002025158,"about_ca_system_score_gemma":0.0002437459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003241304,"about_ca_topic_score_gemma":0.0003624909,"domain_scores_codex":[0.9998971,0.00001946766,0.000009818479,0.00002150894,0.0000304708,0.00002162511],"domain_scores_gemma":[0.9997185,0.00006287322,0.0001304564,0.00002039685,0.00002450317,0.00004313452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001846383,0.000009571132,0.0008664323,0.00002638524,0.00000353792,0.0002106989,0.0000339521,0.00009101273,0.997259,0.0001203263,0.000008470824,0.001185855],"study_design_scores_gemma":[0.00003955928,0.0006924028,0.04010499,0.00001765655,0.00004520725,0.002533889,0.0001337536,0.002606812,0.9523451,0.0003850472,0.001070372,0.00002523581],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974855,0.0006027011,0.001563393,0.00004281641,0.000006830324,0.000006075121,0.00002107812,0.00001629276,0.0002553095],"genre_scores_gemma":[0.9988372,0.0001789693,0.0008119407,0.00002904141,0.000004397746,0.000004888978,0.00003278584,0.00000320509,0.00009760395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005313896,"threshold_uncertainty_score":0.001469433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01076998098702907,"score_gpt":0.2138309681223372,"score_spread":0.2030609871353081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}