{"id":"W2092023463","doi":"10.1186/1479-0556-6-5","title":"Organ distribution of transgene expression following intranasal mucosal delivery of recombinant replication-defective adenovirus gene transfer vector","year":2008,"lang":"en","type":"article","venue":"Genetic Vaccines and Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Nasal administration; Viral vector; Transgene; Gene delivery; Medicine; Genetic enhancement; Virology; Respiratory tract; Immunology; Reporter gene; Olfactory bulb; Biology; Recombinant DNA; Respiratory system; Gene; Gene expression; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001838021,0.0001996744,0.0002861449,0.00005482892,0.0001177744,0.000005533731,0.0001869724,0.0001498169,0.00002964967],"category_scores_gemma":[0.00001334834,0.0001737079,0.0001699418,0.0001733733,0.00006864332,0.000006574013,0.00002370544,0.00007797838,6.456324e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001120916,"about_ca_system_score_gemma":0.0001103049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000557584,"about_ca_topic_score_gemma":0.00002609425,"domain_scores_codex":[0.998625,0.0001273596,0.0003663553,0.0004506252,0.0001914857,0.0002391594],"domain_scores_gemma":[0.9991706,0.00002240019,0.00006868628,0.0004987859,0.0001532001,0.00008631696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002569382,0.0001669111,0.007281395,0.00001886597,0.0001383888,0.000002994403,0.0001993999,0.00004454611,0.9751793,0.00000354566,0.00005402922,0.01434125],"study_design_scores_gemma":[0.00241688,0.002729855,0.06928982,0.00001611915,0.00001945252,0.00002147393,0.00002783844,0.00002894964,0.9249547,0.00004516384,0.0002777937,0.0001719346],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834365,0.01340015,0.002529495,0.00007272734,0.00009601592,0.0004001219,0.00004909889,0.00001008782,0.000005777137],"genre_scores_gemma":[0.978543,0.02086462,0.0002207346,0.00002930335,0.00009100619,0.00003487645,0.0001568383,0.00003441568,0.00002521907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06200842,"threshold_uncertainty_score":0.7083603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0162238415824942,"score_gpt":0.2618460959910581,"score_spread":0.2456222544085639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}