{"id":"W2092023463","doi":"10.1186/1479-0556-6-5","title":"Organ distribution of transgene expression following intranasal mucosal delivery of recombinant replication-defective adenovirus gene transfer vector","year":2008,"lang":"en","type":"article","venue":"Genetic Vaccines and Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Nasal administration; Viral vector; Transgene; Gene delivery; Medicine; Genetic enhancement; Virology; Respiratory tract; Immunology; Reporter gene; Olfactory bulb; Biology; Recombinant DNA; Respiratory system; Gene; Gene expression; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002226175,0.0002742768,0.0002531749,0.0004687361,0.000137389,0.0005178506,0.0001968189,0.0003037798,0.001042511],"category_scores_gemma":[0.0001606265,0.0001392656,0.0003242333,0.0003019347,0.0003772243,0.0003205115,0.0002079666,0.001133509,0.0004140074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003496302,"about_ca_system_score_gemma":0.000307247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001242219,"about_ca_topic_score_gemma":0.001047678,"domain_scores_codex":[0.9998099,0.00001375139,0.00001021017,0.000072846,0.00003803886,0.00005521932],"domain_scores_gemma":[0.9997738,0.00006107974,0.00005516479,0.0000247416,0.00004047954,0.00004472705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007759929,0.00001881583,0.0001681806,0.00002757134,0.000003718502,0.00003488091,0.00004368842,0.00003504048,0.9984466,0.00007005814,0.00001547627,0.00105835],"study_design_scores_gemma":[0.00000805754,0.0004739682,0.009011423,0.000009939643,0.0000233988,0.0001675591,0.0001285011,0.0009060309,0.9885445,0.00008074229,0.0006359316,0.000009934989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.973963,0.002513477,0.01811935,0.000109404,0.00008235747,0.00008650947,0.0009947541,0.0003327128,0.003798458],"genre_scores_gemma":[0.9858661,0.00128504,0.007064182,0.00007052281,0.00001397708,0.00007937339,0.0008045402,0.00006042303,0.004755805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001242219,"threshold_uncertainty_score":0.003487587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0162238415824942,"score_gpt":0.2618460959910581,"score_spread":0.2456222544085639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}