{"id":"W2092026235","doi":"10.1002/1521-4184(200010)333:10<347::aid-ardp347>3.0.co;2-6","title":"Synthesis andin Vitro Antifungal and Cytotoxicity Evaluation of Thiazolo-4H-1,2,4-triazoles and 1,2,3-Thiadiazolo-4H-1,2,4-triazoles","year":2000,"lang":"en","type":"article","venue":"Archiv der Pharmazie","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; University of Alberta","funders":"","keywords":"Aspergillus fumigatus; Chemistry; Cytotoxicity; Candida albicans; Thiadiazoles; In vitro; Toxicity; Cryptococcus neoformans; Antifungal; Cryptococcus; Stereochemistry; Nuclear chemistry; Microbiology; Medicinal chemistry; Organic chemistry; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001294507,0.0004181403,0.0002497075,0.0002383482,0.0002013827,0.0001786232,0.0002777411,0.0002444054,0.00123632],"category_scores_gemma":[0.0002027201,0.0001629844,0.000253323,0.0004110818,0.0001747302,0.0002251936,0.0001228863,0.000248259,0.0005455459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002834434,"about_ca_system_score_gemma":0.0004107831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00103341,"about_ca_topic_score_gemma":0.001960485,"domain_scores_codex":[0.9999118,0.00001343215,0.00001369514,0.00001500731,0.00003072954,0.00001526958],"domain_scores_gemma":[0.9998773,0.0000176575,0.00003272079,0.00001407715,0.00003876207,0.00001934579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001074623,0.00004672989,0.0001458708,0.0002153447,0.000007989503,0.0001136479,0.00002086875,0.0004950481,0.9939113,0.0001459806,0.00007416245,0.004715702],"study_design_scores_gemma":[0.00002710043,0.00100975,0.001556231,0.00001228474,0.00002488384,0.0002133509,0.00001960779,0.0004867043,0.9916046,0.00004179732,0.004995529,0.000008145998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9525477,0.02305679,0.01342396,0.0001720175,0.0001104892,0.0002920753,0.002749967,0.0002295527,0.007417327],"genre_scores_gemma":[0.9516163,0.01693197,0.01932482,0.00009583382,0.00004428187,0.0002095184,0.004715431,0.00004363228,0.007018203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00123632,"threshold_uncertainty_score":0.004135907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0395431791501912,"score_gpt":0.2824627501410119,"score_spread":0.2429195709908207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}