{"id":"W2092026235","doi":"10.1002/1521-4184(200010)333:10<347::aid-ardp347>3.0.co;2-6","title":"Synthesis andin Vitro Antifungal and Cytotoxicity Evaluation of Thiazolo-4H-1,2,4-triazoles and 1,2,3-Thiadiazolo-4H-1,2,4-triazoles","year":2000,"lang":"en","type":"article","venue":"Archiv der Pharmazie","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; University of Alberta","funders":"","keywords":"Aspergillus fumigatus; Chemistry; Cytotoxicity; Candida albicans; Thiadiazoles; In vitro; Toxicity; Cryptococcus neoformans; Antifungal; Cryptococcus; Stereochemistry; Nuclear chemistry; Microbiology; Medicinal chemistry; Organic chemistry; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001490183,0.0004689837,0.0007411541,0.0001291867,0.0002869278,0.00008561633,0.0003251217,0.0002520462,0.004371755],"category_scores_gemma":[0.0006470724,0.0003758131,0.0001884096,0.000177931,0.0005643826,0.0002740515,0.0001626946,0.0004022233,0.0000265531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005263708,"about_ca_system_score_gemma":0.00008653122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001039602,"about_ca_topic_score_gemma":0.00001329645,"domain_scores_codex":[0.9968472,0.0004122576,0.0006269605,0.0008251372,0.0007090045,0.0005794654],"domain_scores_gemma":[0.9971792,0.001739861,0.0002560049,0.0004407603,0.0001065911,0.000277622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007170792,0.0003521459,0.01876861,0.0001343929,0.0002172984,0.000007561812,0.0001807977,0.00001242125,0.7093223,0.00004810621,0.0002295029,0.2700098],"study_design_scores_gemma":[0.001577645,0.00004287788,0.06591775,0.0001056036,0.0004876704,0.00005945347,0.00010136,0.003692085,0.9248679,0.002025731,0.0006243038,0.0004976784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851816,0.001616094,0.00001584907,0.0003565551,0.0000557086,0.0003234502,0.0003247931,0.0001197071,0.01200629],"genre_scores_gemma":[0.9972183,0.001720849,0.0004334781,0.0001399257,0.0002583746,0.00008102549,0.00003711443,0.00003565751,0.00007531649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2695121,"threshold_uncertainty_score":0.9998694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0395431791501912,"score_gpt":0.2824627501410119,"score_spread":0.2429195709908207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}