{"id":"W2092071708","doi":"10.1016/j.brainres.2009.07.068","title":"Resistin differentially modulates neuropeptide gene expression and AMP-activated protein kinase activity in N-1 hypothalamic neurons","year":2009,"lang":"en","type":"article","venue":"Brain Research","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University","funders":"IWK Health Centre; Nova Scotia Health Research Foundation","keywords":"Resistin; Internal medicine; Endocrinology; Adipokine; Adiponectin; Hypothalamus; Neuropeptide Y receptor; Biology; Protein kinase A; Gene expression; Western blot; AMPK; Chemistry; Kinase; Neuropeptide; Medicine; Insulin; Insulin resistance; Gene; Cell biology; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001086381,0.0002540379,0.0003399743,0.0002425849,0.0002022486,0.0004054779,0.0001859048,0.000294981,0.001623732],"category_scores_gemma":[0.0002534846,0.0001912487,0.000251791,0.0001306367,0.000341027,0.0004268912,0.0002658749,0.0007023856,0.0002498535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003010672,"about_ca_system_score_gemma":0.0001252689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004438059,"about_ca_topic_score_gemma":0.0008793225,"domain_scores_codex":[0.999851,0.00001977532,0.00000826853,0.00003713453,0.00001565249,0.00006819144],"domain_scores_gemma":[0.9998971,0.00002548999,0.0000217366,0.00001338166,0.000006227985,0.00003609691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008578055,0.00002046463,0.0002574866,0.00001471947,0.000003449997,0.00007016926,0.00001631234,0.00001802871,0.9980867,0.00005831032,0.00001751735,0.0005790864],"study_design_scores_gemma":[0.0002680873,0.001507305,0.108529,0.00002651138,0.00004850262,0.001060992,0.0003643827,0.001233845,0.8846698,0.0005787109,0.001685945,0.00002698947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987687,0.0002660286,0.0002499083,0.00005624774,0.00001670092,0.000004049621,0.00007131699,0.000005850868,0.0005611806],"genre_scores_gemma":[0.9968022,0.0003766242,0.0004924611,0.00007431448,0.00002381353,0.00002224228,0.0002307872,0.00001300441,0.00196445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001623732,"threshold_uncertainty_score":0.00543189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08025479408381322,"score_gpt":0.3372778837662238,"score_spread":0.2570230896824105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}