{"id":"W2092073971","doi":"10.1038/nature02951","title":"Enhanced virulence of influenza A viruses with the haemagglutinin of the 1918 pandemic virus","year":2004,"lang":"en","type":"article","venue":"Nature","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":461,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Health Canada","funders":"National Institute of Allergy and Infectious Diseases; Fundação para a Ciência e a Tecnologia; Howard Hughes Medical Institute; Ministry of Education, Culture, Sports, Science and Technology; Health Canada; Core Research for Evolutional Science and Technology; Japan Science and Technology Corporation","keywords":"Virology; Virulence; Virus; Biology; Neuraminidase; Pandemic; Microbiology; H5N1 genetic structure; Outbreak; Influenza A virus; Influenza A virus subtype H5N1; Reverse genetics; Gene; Infectious disease (medical specialty); Genome; Genetics; Disease; Coronavirus disease 2019 (COVID-19); Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002869233,0.0003366537,0.000192541,0.0001966848,0.0001553449,0.0003353054,0.0002076658,0.0003915303,0.001399531],"category_scores_gemma":[0.0004316883,0.0001419727,0.000388482,0.0001011296,0.0002381536,0.0002856952,0.0003433643,0.0005852755,0.0003520722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002400711,"about_ca_system_score_gemma":0.0001495113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007564267,"about_ca_topic_score_gemma":0.0004501656,"domain_scores_codex":[0.9997212,0.0001061301,0.00001646093,0.00002154745,0.00005781226,0.00007681606],"domain_scores_gemma":[0.9997523,0.00009191292,0.00003152623,0.00004061815,0.00004033059,0.00004328813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002760606,0.00005716925,0.0007896271,0.00001306728,0.00001038231,0.00007400686,0.00002789331,0.00007505632,0.997843,0.0001165512,0.00003112344,0.0006860896],"study_design_scores_gemma":[0.00006887437,0.002895628,0.03418314,0.00001005232,0.00004081894,0.001294737,0.0001537916,0.001771655,0.9576079,0.0002263282,0.001732115,0.00001502056],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990107,0.0001378609,0.0002424374,0.00002356926,0.00001077901,0.000004312518,0.00002993715,0.00000504144,0.0005352614],"genre_scores_gemma":[0.9986548,0.00007661224,0.0003354429,0.00001932969,0.00000712929,0.000003060657,0.0001418407,0.000005404723,0.0007562665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001399531,"threshold_uncertainty_score":0.004681826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04495122821671538,"score_gpt":0.3706720859750815,"score_spread":0.3257208577583661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}