{"id":"W2092096790","doi":"10.1038/jid.2013.378","title":"Is a Single BRAF Wild-Type Test Sufficient to Exclude Melanoma Patients from Vemurafenib Therapy?","year":2013,"lang":"en","type":"letter","venue":"Journal of Investigative Dermatology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hotel Dieu Hospital","funders":"Institut National Du Cancer","keywords":"Vemurafenib; Medicine; Melanoma; Dermatology; Test (biology); Oncology; Internal medicine; Cancer research; Metastatic melanoma; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001219655,0.0004249806,0.001118243,0.0005688109,0.001150914,0.001172471,0.0009150961,0.01313825,0.002524962],"category_scores_gemma":[0.01309827,0.0003845827,0.0009457582,0.0003716796,0.00124923,0.001837321,0.0004579434,0.008520845,0.00222693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001418549,"about_ca_system_score_gemma":0.0009958924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0017195,"about_ca_topic_score_gemma":0.002709415,"domain_scores_codex":[0.9990282,0.000277722,0.0001712603,0.0001197484,0.0002103561,0.0001927503],"domain_scores_gemma":[0.9966021,0.002002224,0.0002111614,0.0001326973,0.0004888142,0.00056309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001542029,0.0004044968,0.06476805,0.000369572,0.0002112178,0.2201419,0.0003990481,0.0008496672,0.005123342,0.006122532,0.5894281,0.1106402],"study_design_scores_gemma":[0.001157105,0.001127602,0.047045,0.001041725,0.0005234267,0.4703663,0.001954822,0.007204922,0.004995485,0.04829197,0.415994,0.0002977131],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.02312141,0.003799155,0.0008493442,0.9519466,0.0106772,0.00003514267,0.0001632487,0.0000850836,0.009322778],"genre_scores_gemma":[0.3399672,0.00584025,0.003639588,0.5531896,0.09061649,0.00007753812,0.0002149962,0.00006872341,0.006385604],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01313825,"threshold_uncertainty_score":0.01029229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03078801824767424,"score_gpt":0.2380656927843419,"score_spread":0.2072776745366677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}