{"id":"W2092097657","doi":"10.1139/o05-119","title":"Lsh, a guardian of heterochromatin at repeat elements","year":2005,"lang":"en","type":"review","venue":"Biochemistry and Cell Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; U.S. Public Health Service; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Heterochromatin; Euchromatin; Biology; EZH2; Chromatin; Heterochromatin protein 1; Epigenetics; Genetics; Genome instability; Histone; Helicase; DNA methylation; Mitosis; Cell biology; Chromodomain; DNA; Gene; Gene expression; DNA damage","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003255587,0.0009186999,0.0008805257,0.001277794,0.0002592277,0.0008150238,0.000864885,0.0009657692,0.002774067],"category_scores_gemma":[0.0002896531,0.0002093337,0.0001778367,0.001384994,0.0005302019,0.0009475743,0.0004252039,0.001094239,0.004608319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006373996,"about_ca_system_score_gemma":0.0006045642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006973509,"about_ca_topic_score_gemma":0.001053935,"domain_scores_codex":[0.9999149,0.00000925485,0.000008395761,0.00002579525,0.00003243834,0.000009243233],"domain_scores_gemma":[0.9998351,0.00004316606,0.00003296266,0.000008056206,0.00004612767,0.00003441931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000065819,0.00003809134,0.0002235791,0.003543456,0.00003849417,0.0002285637,0.00003027647,0.0003138133,0.010366,0.003017581,0.01957916,0.9625551],"study_design_scores_gemma":[0.000011961,0.00005367292,0.0007105944,0.0003769128,0.00003525069,0.001378772,0.0000282814,0.00006832508,0.002782505,0.001088771,0.9934541,0.00001086208],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003891844,0.996094,0.0005545829,0.0002045041,0.0002007293,0.000004382332,0.00002339424,0.00002766348,0.002501494],"genre_scores_gemma":[0.003144102,0.9915233,0.0006968068,0.0002393221,0.0001993847,0.00001118639,0.0001084234,0.000005393957,0.004072079],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002774067,"threshold_uncertainty_score":0.009280145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01832800837804813,"score_gpt":0.3020680948344622,"score_spread":0.283740086456414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}