{"id":"W2092097657","doi":"10.1139/o05-119","title":"Lsh, a guardian of heterochromatin at repeat elements","year":2005,"lang":"en","type":"review","venue":"Biochemistry and Cell Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; U.S. Public Health Service; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Heterochromatin; Euchromatin; Biology; EZH2; Chromatin; Heterochromatin protein 1; Epigenetics; Genetics; Genome instability; Histone; Helicase; DNA methylation; Mitosis; Cell biology; Chromodomain; DNA; Gene; Gene expression; DNA damage","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000198973,0.0003983059,0.0007960121,0.00004632867,0.00006772018,0.000009085132,0.0002368366,0.0009198631,0.00006435474],"category_scores_gemma":[0.00004336105,0.0003524196,0.0003194574,0.00006742955,0.0001620246,0.000001169096,0.0003210584,0.0001270062,0.00001117923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003150423,"about_ca_system_score_gemma":0.0001007902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004511085,"about_ca_topic_score_gemma":0.000003232706,"domain_scores_codex":[0.9981619,0.0001127255,0.0006830116,0.0006753979,0.00007273273,0.0002943036],"domain_scores_gemma":[0.9987232,0.00002600943,0.0005268946,0.0005608759,0.00004833677,0.0001146643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001503976,0.00005643195,0.0000683882,0.003466991,0.0001144723,0.000001385823,0.000006811933,2.267348e-7,0.3990275,0.000002952686,0.0002377784,0.597002],"study_design_scores_gemma":[0.0001808139,0.0001667287,0.00000182621,0.0002455453,0.000134515,0.000008345354,0.000003727558,6.131265e-7,0.2676781,0.000006153368,0.7313122,0.0002613856],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02250934,0.9733822,0.0000184442,0.000004835156,0.00009182617,0.0002380036,0.0002052566,0.000007526334,0.003542615],"genre_scores_gemma":[0.006285659,0.9882451,0.0005046522,0.00001693032,0.0003806149,0.00004173057,0.002344819,0.00003609998,0.002144427],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7310745,"threshold_uncertainty_score":0.9998928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01832800837804813,"score_gpt":0.3020680948344622,"score_spread":0.283740086456414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}