{"id":"W2092112974","doi":"10.1159/000338131","title":"Biologic Therapies: Lessons from Multiple Sclerosis","year":2012,"lang":"en","type":"review","venue":"Digestive Diseases","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Multiple sclerosis; Ustekinumab; Immunology; Natalizumab; Secukinumab; Etanercept; Glatiramer acetate; Adalimumab; Inflammatory bowel disease; Tumor necrosis factor alpha; Fingolimod; Cytokine; Vedolizumab; Interleukin 23; Rheumatoid arthritis; Disease; Interleukin; Psoriatic arthritis; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00007340653,0.0007000371,0.0008711185,0.00008010476,0.0001609121,0.00005768519,0.0005458521,0.0004671093,0.0001581099],"category_scores_gemma":[0.0003247641,0.0005561974,0.000927425,0.0001053027,0.0002561369,0.000008364796,0.0002854522,0.0001699552,0.0003431873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005318883,"about_ca_system_score_gemma":0.0003334079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002081504,"about_ca_topic_score_gemma":0.000008628516,"domain_scores_codex":[0.9976947,0.0003872449,0.0004021327,0.0008141243,0.0001685619,0.0005332385],"domain_scores_gemma":[0.9981856,0.0001481353,0.0003288223,0.0008438181,0.00009880863,0.0003948634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001683073,0.0006237943,0.02401821,0.00227817,0.001550338,0.00007195091,0.0000457005,0.000001914665,0.0001653308,0.00009182455,0.001732033,0.9692524],"study_design_scores_gemma":[0.000289928,0.00003866245,0.06688701,0.001570782,0.00166055,0.00000153314,0.00003749926,6.90182e-7,0.00001499274,0.00002250817,0.9286817,0.0007941372],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004317484,0.9853411,0.00002544252,0.000009859074,0.0003250847,0.0007257161,0.00903747,0.00006733326,0.000150488],"genre_scores_gemma":[0.01046388,0.9770891,0.00005519764,0.0001107127,0.0009171821,0.0005467586,0.01050248,0.0001159094,0.0001987646],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9684583,"threshold_uncertainty_score":0.9996889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08309242083720102,"score_gpt":0.3146186343149057,"score_spread":0.2315262134777046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}