{"id":"W2092116730","doi":"10.3389/fendo.2014.00068","title":"Allosteric and Biased G Protein-Coupled Receptor Signaling Regulation: Potentials for New Therapeutics","year":2014,"lang":"en","type":"review","venue":"Frontiers in Endocrinology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; McGill University","keywords":"Allosteric regulation; G protein-coupled receptor; Functional selectivity; Signal transduction; Receptor; G protein; Drug discovery; Cell biology; Biology; Cell signaling; Chemistry; Computational biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005842764,0.0007249528,0.001225129,0.001135718,0.0002395534,0.0008826685,0.0009102928,0.00115192,0.003281397],"category_scores_gemma":[0.0005504605,0.0002494453,0.00048741,0.001179512,0.000667463,0.001521556,0.0006811536,0.002370042,0.001779983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007728224,"about_ca_system_score_gemma":0.0006902211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003618497,"about_ca_topic_score_gemma":0.0006791445,"domain_scores_codex":[0.9998232,0.00003780083,0.00001865201,0.00003612524,0.00006056199,0.00002379344],"domain_scores_gemma":[0.9998332,0.0000796957,0.00001949653,0.000008101154,0.00003882673,0.00002049404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001305162,0.0001389102,0.0001462581,0.01255277,0.00007755348,0.0004480667,0.00009191024,0.0009403237,0.008542233,0.02392671,0.02872312,0.9242816],"study_design_scores_gemma":[0.00002689749,0.0001272533,0.0004294294,0.001338054,0.00005930887,0.001174864,0.00005378526,0.0002429304,0.001386734,0.006777563,0.9883592,0.00002401811],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003324428,0.996073,0.0005828022,0.0006767994,0.0003404883,0.000006275131,0.00002292863,0.00001781511,0.001947406],"genre_scores_gemma":[0.001877034,0.9960622,0.0004608521,0.0003767202,0.0002527815,0.00001050772,0.00003286845,0.000002872249,0.0009242286],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003281397,"threshold_uncertainty_score":0.01097733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03345765983320658,"score_gpt":0.2942474594188937,"score_spread":0.2607897995856872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}