{"id":"W2092151221","doi":"10.1073/pnas.1105601108","title":"Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":143,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Health and Medical Research Council; National Institutes of Health; Australian Synchrotron; McGill University; Medical Research Council; University of Pennsylvania","keywords":"Biology; Plasmodium falciparum; Malaria; Drug discovery; Proteolysis; Enzyme; Biochemistry; Cell biology; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000597349,0.00008988735,0.0002076812,0.0001333712,0.0000970389,0.000009917047,0.0001953441,0.00008049253,0.00002881895],"category_scores_gemma":[0.0005799012,0.00005681611,0.00008891588,0.0003113927,0.001008348,0.0001133945,0.00003138043,0.00008982801,4.580213e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001349133,"about_ca_system_score_gemma":0.00003891946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007961343,"about_ca_topic_score_gemma":8.131902e-8,"domain_scores_codex":[0.9989961,0.00000505217,0.0003032437,0.0002230837,0.0003394292,0.0001330295],"domain_scores_gemma":[0.9992212,0.0001398625,0.0002864534,0.00000748266,0.0002890582,0.00005591174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007227065,0.0001079847,0.03391544,0.0001337233,0.00002418065,1.301161e-8,0.00005829571,0.000001117735,0.9212977,0.04323777,0.0005185114,0.0006329956],"study_design_scores_gemma":[0.0006671294,0.000242985,0.3183126,0.0003800851,0.00007438885,0.000006500106,0.0003013526,0.001157104,0.6357994,0.04290329,0.000047776,0.0001073331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944749,0.00006133602,0.000007801126,0.001451076,0.00000236644,0.000177348,0.0001115038,0.00001070913,0.003702965],"genre_scores_gemma":[0.9949363,0.000004867435,0.00438054,0.0005348367,0.000046017,0.00001840815,0.000001593131,0.000003523719,0.00007389727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2854983,"threshold_uncertainty_score":0.3715302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08871999188317524,"score_gpt":0.3355366075900691,"score_spread":0.2468166157068939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}