{"id":"W2092151221","doi":"10.1073/pnas.1105601108","title":"Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":143,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Health and Medical Research Council; National Institutes of Health; Australian Synchrotron; McGill University; Medical Research Council; University of Pennsylvania","keywords":"Biology; Plasmodium falciparum; Malaria; Drug discovery; Proteolysis; Enzyme; Biochemistry; Cell biology; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001590403,0.0003735865,0.0002271651,0.000151559,0.0001336832,0.0002558593,0.0002104351,0.0003650907,0.0004508961],"category_scores_gemma":[0.0001222111,0.0001859839,0.0002218174,0.00009071879,0.0002665269,0.0001933682,0.0001733741,0.0005557172,0.0002140475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003064636,"about_ca_system_score_gemma":0.000173011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004221947,"about_ca_topic_score_gemma":0.0007398225,"domain_scores_codex":[0.9998788,0.00002468457,0.00000943017,0.00003297281,0.0000258172,0.00002833732],"domain_scores_gemma":[0.9999275,0.00001633882,0.00002405247,0.000009097581,0.000009481627,0.000013458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004414312,0.00001427651,0.00004567033,0.00001559428,0.000003691323,0.00002472354,0.000007189513,0.00009294356,0.9989962,0.00008411314,0.0000159076,0.0006555366],"study_design_scores_gemma":[0.000004024024,0.00008039825,0.0002834013,0.000001161552,0.000004927131,0.00007919883,0.000004187381,0.0003608617,0.9984688,0.0000162435,0.000694944,0.000001853202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9765143,0.001416581,0.01897046,0.000300702,0.00003047515,0.00007042669,0.0002143625,0.000093713,0.002388963],"genre_scores_gemma":[0.9830599,0.00100013,0.01287161,0.0001429863,0.000006766107,0.00003465607,0.0003099928,0.00002141836,0.002552453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004508961,"threshold_uncertainty_score":0.002223492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08871999188317524,"score_gpt":0.3355366075900691,"score_spread":0.2468166157068939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}