{"id":"W2092168005","doi":"10.1016/j.clinbiochem.2014.06.027","title":"Newborn screening for hemoglobinopathies using HPLC and capillary electrophoresis: Initial findings from the Quebec Newborn Blood Screening Program","year":2014,"lang":"en","type":"article","venue":"Clinical Biochemistry","topic":"Paraoxonase enzyme and polymorphisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Internal medicine; Endocrinology; Arylesterase; Paraoxonase; Apolipoprotein B; Cholesterol; High-density lipoprotein; Chemistry; Lipoprotein; PON1; Medicine; Biochemistry; Oxidative stress; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005631732,0.0006255547,0.0003792892,0.001269666,0.001463347,0.0004819958,0.0006274221,0.0007193554,0.001518968],"category_scores_gemma":[0.002110077,0.0002503314,0.000304305,0.001370506,0.0003505109,0.0002400578,0.0003012005,0.0007225303,0.0002338844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0105998,"about_ca_system_score_gemma":0.007050263,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9506059,"about_ca_topic_score_gemma":0.9576233,"domain_scores_codex":[0.9994387,0.00007420732,0.00003881818,0.00007798331,0.0002536638,0.0001165689],"domain_scores_gemma":[0.9985929,0.0001680244,0.00006429991,0.00002120477,0.0008851506,0.000268413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003143307,0.0002636339,0.9505885,0.00008347406,0.00006332633,0.008775087,0.001521713,0.0002965475,0.005540148,0.0001825529,0.005210103,0.02716053],"study_design_scores_gemma":[0.00002112338,0.0001458675,0.9926658,0.00005862511,0.00003991363,0.001572801,0.0007431866,0.0005452286,0.000844109,0.00002100987,0.003327212,0.00001517271],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9751537,0.002870046,0.0008372215,0.002322677,0.00006843836,0.0003809109,0.003688533,0.0000536545,0.01462475],"genre_scores_gemma":[0.9917813,0.001583191,0.001344791,0.0007719989,0.00002488253,0.0000695917,0.001046823,0.00001731715,0.003360066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04939407,"threshold_uncertainty_score":0.09936988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0358768021315514,"score_gpt":0.3366064636711291,"score_spread":0.3007296615395776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}