{"id":"W2092247923","doi":"10.1074/jbc.m114.568147","title":"Differential Regulation of Endosomal GPCR/β-Arrestin Complexes and Trafficking by MAPK","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; McGill University","keywords":"Arrestin; Endosome; G protein-coupled receptor; Cell biology; Biology; Receptor; Signal transduction; MAPK/ERK pathway; Endocytosis; G protein; Intracellular; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001655008,0.0001088814,0.0002216233,0.0000107444,0.00003658637,0.0000133472,0.0001219086,0.0001809457,0.00014944],"category_scores_gemma":[0.0001373869,0.00007869345,0.00009926109,0.00002437008,0.00007355189,0.000003029602,0.00004722139,0.0001071943,1.868061e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005117853,"about_ca_system_score_gemma":0.00001185063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":8.566262e-7,"about_ca_topic_score_gemma":1.098549e-7,"domain_scores_codex":[0.999244,0.00004495642,0.000339297,0.0001401284,0.0001091168,0.0001224561],"domain_scores_gemma":[0.9994261,0.0000329727,0.0003092994,0.00008086877,0.00007334082,0.00007739951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009618681,0.00004144364,0.001507449,0.00002123628,0.00002258891,5.094141e-7,0.000007329556,0.00001817043,0.9960147,0.00002204194,0.0001958369,0.002052471],"study_design_scores_gemma":[0.0004701146,0.0002902148,0.002107874,0.00002837532,0.00001230405,0.00004304324,0.00002651321,0.0001100837,0.9950175,0.0001765912,0.001624846,0.00009257053],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939571,0.0003855111,0.005386857,0.00003088643,0.00006011952,0.00002589162,0.000007431478,0.000003093606,0.0001431258],"genre_scores_gemma":[0.9985992,0.00006940683,0.0008856746,0.00001982261,0.0003429047,6.220818e-7,0.00003258803,0.000006165772,0.00004361581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004642116,"threshold_uncertainty_score":0.3209026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01227810773324934,"score_gpt":0.2237986811387707,"score_spread":0.2115205734055214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}