{"id":"W2092265599","doi":"10.1158/1538-7445.am2014-4575","title":"Abstract 4575: Structure-based design, synthesis and biological testing of highly potent semi-synthetic epipodophyllotoxin-derived hybrid etoposide analogs","year":2014,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Etoposide; Topoisomerase; DNA; Chemistry; Cell cycle; Biology; Biochemistry; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001534209,0.000277341,0.0002294923,0.0001893311,0.00009269041,0.0002680731,0.0002787024,0.0002096743,0.001190549],"category_scores_gemma":[0.0001523235,0.0001057161,0.0001585753,0.0001838366,0.0001191538,0.0001712073,0.000208473,0.0002829374,0.0003389121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002955254,"about_ca_system_score_gemma":0.0002004432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000330658,"about_ca_topic_score_gemma":0.0005778325,"domain_scores_codex":[0.99988,0.00002435196,0.00001577956,0.00002225275,0.0000383105,0.00001943991],"domain_scores_gemma":[0.9999168,0.00001077248,0.00002124856,0.000008605787,0.00001563056,0.00002697522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000143105,0.0001177767,0.0002416693,0.00005015159,0.00001400861,0.00007021526,0.0000247688,0.001716076,0.9930462,0.0003290281,0.00004956494,0.004197505],"study_design_scores_gemma":[0.00009796337,0.002962605,0.001735179,0.000009901104,0.00003360751,0.0001673036,0.00002465289,0.001633794,0.9886448,0.00007710262,0.004605225,0.000007851301],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867775,0.0007742553,0.008671769,0.00004150097,0.00002209644,0.0002375115,0.0005791073,0.00004525902,0.002851001],"genre_scores_gemma":[0.9890021,0.0005399147,0.007337715,0.00003739892,0.00000501245,0.00008223594,0.0009828325,0.00001456827,0.001998123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001190549,"threshold_uncertainty_score":0.003982782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0842697062649842,"score_gpt":0.330991049870687,"score_spread":0.2467213436057028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}