{"id":"W2092269740","doi":"10.1074/mcp.m114.042168","title":"KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and Lysosome-Mediated Degradation*","year":2015,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Princess Margaret Cancer Centre; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"Ubiquitin; Ubiquitin ligase; Endosome; Lysosome; Cell biology; Ubiquitin-conjugating enzyme; Biology; Ubiquitin-Protein Ligases; Autophagy; Biochemistry; Chemistry; Intracellular; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001626576,0.0005997882,0.0002418285,0.0002354746,0.000263348,0.0003022441,0.0002315043,0.0005179081,0.001330097],"category_scores_gemma":[0.000174548,0.0002113847,0.0002467515,0.0001159218,0.0001878778,0.0002686408,0.0003242664,0.0002752836,0.0006993312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004963261,"about_ca_system_score_gemma":0.0001126952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005827767,"about_ca_topic_score_gemma":0.0005694108,"domain_scores_codex":[0.9998584,0.00001878327,0.00001058539,0.00004254234,0.0000245283,0.00004506611],"domain_scores_gemma":[0.9998913,0.00001410475,0.00005284752,0.000009263073,0.00001120442,0.00002132467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001517434,0.00001941235,0.002495796,0.00005234038,0.00001548686,0.0002760029,0.00001219778,0.0001071913,0.9944488,0.00009349707,0.00005748394,0.002270049],"study_design_scores_gemma":[0.00001544625,0.0001625635,0.03516991,0.000007341507,0.00002410592,0.00176773,0.00002356831,0.001329374,0.9583414,0.0001083933,0.003041743,0.000008448322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923353,0.002935738,0.003631925,0.00009693606,0.00001883142,0.0000160025,0.0001769687,0.00007795756,0.0007103863],"genre_scores_gemma":[0.9936925,0.0006933939,0.002981641,0.00005880261,0.00001075507,0.00001161311,0.0004308543,0.00001073073,0.002109555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001330097,"threshold_uncertainty_score":0.004449666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02269818423841016,"score_gpt":0.2543980288805862,"score_spread":0.231699844642176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}