{"id":"W2092269740","doi":"10.1074/mcp.m114.042168","title":"KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and Lysosome-Mediated Degradation*","year":2015,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Princess Margaret Cancer Centre; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"Ubiquitin; Ubiquitin ligase; Endosome; Lysosome; Cell biology; Ubiquitin-conjugating enzyme; Biology; Ubiquitin-Protein Ligases; Autophagy; Biochemistry; Chemistry; Intracellular; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005783325,0.0004898303,0.0006238911,0.000309611,0.000175977,0.00008942921,0.0002203209,0.0004910628,0.0000484104],"category_scores_gemma":[0.0003002394,0.0004868597,0.0001854171,0.0003649787,0.0001108226,0.0001438095,0.0001578379,0.0007322809,0.0001475435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002214731,"about_ca_system_score_gemma":0.000428588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004247949,"about_ca_topic_score_gemma":0.000002511004,"domain_scores_codex":[0.9972472,0.0002173596,0.0005639729,0.0007416885,0.0005719477,0.0006577898],"domain_scores_gemma":[0.9976498,0.0000409606,0.000206601,0.0006618275,0.0002798327,0.00116091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006386999,0.0002733834,0.0006241915,0.0001052867,0.0002817123,0.001032979,0.001832162,0.00007487187,0.9921824,0.0002324383,0.0002417021,0.002480183],"study_design_scores_gemma":[0.004593352,0.0007720747,0.0008251501,0.0001528142,0.0001364242,0.00006057443,0.0004666905,0.002634258,0.9867513,0.00154532,0.001482682,0.0005794042],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9703251,0.00183888,0.02323723,0.001705936,0.0002320248,0.002145621,0.00006756403,0.0002043684,0.0002433253],"genre_scores_gemma":[0.9875696,0.00004243665,0.00788383,0.003062628,0.0002827925,0.0002090844,0.0003705941,0.0001452343,0.0004337569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01724459,"threshold_uncertainty_score":0.9997583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02269818423841016,"score_gpt":0.2543980288805862,"score_spread":0.231699844642176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}