{"id":"W2092329631","doi":"10.1074/jbc.m800321200","title":"The RalA GTPase Is a Central Regulator of Insulin Exocytosis from Pancreatic Islet Beta Cells","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Exocytosis; Exocyst; Cell biology; Pancreatic islets; Insulin; Biology; Beta cell; Islet; Internal medicine; Secretion; Endocrinology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001510329,0.0004453037,0.0003728852,0.0002676259,0.000204918,0.0006257369,0.0002084227,0.0002809935,0.0007999689],"category_scores_gemma":[0.0001186634,0.0001664246,0.0004605839,0.0001207954,0.0002123487,0.0002811626,0.0003763655,0.0007287244,0.0005675356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002791194,"about_ca_system_score_gemma":0.0001824936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002223326,"about_ca_topic_score_gemma":0.0002110321,"domain_scores_codex":[0.9998462,0.00001956154,0.00001800891,0.00004559982,0.00004651676,0.00002408962],"domain_scores_gemma":[0.9999137,0.0000142776,0.00002054594,0.00001496936,0.00001148546,0.00002510142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003497665,0.000004850784,0.00009757939,0.00001566326,0.000002563454,0.00005083673,0.000005555748,0.00001939435,0.9988981,0.0000724509,0.0000179969,0.0007799349],"study_design_scores_gemma":[0.00001168543,0.00007234641,0.004867305,0.000007951629,0.00001429091,0.0004740647,0.00001990217,0.0009655663,0.9897405,0.0000555561,0.003765154,0.000005653001],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9749153,0.007495736,0.01291701,0.0002984808,0.00007136245,0.00005705109,0.0008066129,0.0004707573,0.002967738],"genre_scores_gemma":[0.9867093,0.002177196,0.006174854,0.00008369987,0.00002140461,0.00007183604,0.001012136,0.00007272013,0.003676894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007999689,"threshold_uncertainty_score":0.002676189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02579254371197515,"score_gpt":0.2337627618752263,"score_spread":0.2079702181632512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}