{"id":"W2092334370","doi":"10.1371/journal.pone.0024987","title":"Functional Polymorphisms in the TERT Promoter Are Associated with Risk of Serous Epithelial Ovarian and Breast Cancers","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Health Services","funders":"National Cancer Institute; Medical Research Council; Universität Ulm; University College London Hospitals NHS Foundation Trust; Medical Research and Materiel Command; Deutsche Krebshilfe; National Institute for Health and Care Research; Bundesministerium für Bildung und Forschung; National Breast Cancer Foundation; Breast Cancer Research Trust; Cancer Institute NSW; National Health and Medical Research Council; Cancer Research UK; Deutsches Krebsforschungszentrum; Rutgers Cancer Institute of New Jersey; Cancer Council Tasmania; National Institutes of Health; Ovarian Cancer Research Fund; Canadian Institutes of Health Research; Oak Foundation","keywords":"Single-nucleotide polymorphism; SNP; Minor allele frequency; Allele; Serous fluid; Breast cancer; Biology; Ovarian cancer; Locus (genetics); Promoter; Genotype; Genetics; Cancer research; Gene; Oncology; Medicine; Cancer; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007623542,0.00006530937,0.00007974022,0.00001762673,0.00003245877,0.000004673176,0.00004597838,0.00006798974,0.00003625438],"category_scores_gemma":[0.00001516512,0.00004257843,0.00001522937,0.00004738846,0.00005245962,0.000002892631,0.00001511025,0.00007166636,9.006846e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008786671,"about_ca_system_score_gemma":0.00002106035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002908639,"about_ca_topic_score_gemma":0.000454445,"domain_scores_codex":[0.9995781,0.00004405259,0.00007184951,0.0001263077,0.00009488071,0.00008477029],"domain_scores_gemma":[0.9997501,0.000004001537,0.00007629325,0.0001131397,0.00003873085,0.00001767885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001155954,0.0005324344,0.6028224,0.00001811598,0.0006387141,0.00000781533,0.0007625405,0.000002895472,0.3928217,0.00003222131,0.00015117,0.001054019],"study_design_scores_gemma":[0.0005420966,0.0003171873,0.9686849,0.00003166325,0.00008585271,0.00001650902,0.00006330341,0.00001398639,0.03010303,0.00005807155,0.00001439064,0.00006907477],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993151,0.00003686666,0.00002779357,0.00006373076,0.00001937375,0.0001041465,0.00006352449,0.000003603534,0.0003658461],"genre_scores_gemma":[0.9995255,0.00001442022,0.00016464,0.00009303635,0.00007570293,0.000007486784,0.00003061609,0.000008864368,0.00007972308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3658624,"threshold_uncertainty_score":0.1736298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0171223825523287,"score_gpt":0.1690000925799683,"score_spread":0.1518777100276396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}