{"id":"W2092334370","doi":"10.1371/journal.pone.0024987","title":"Functional Polymorphisms in the TERT Promoter Are Associated with Risk of Serous Epithelial Ovarian and Breast Cancers","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Health Services","funders":"National Cancer Institute; Medical Research Council; Universität Ulm; University College London Hospitals NHS Foundation Trust; Medical Research and Materiel Command; Deutsche Krebshilfe; National Institute for Health and Care Research; Bundesministerium für Bildung und Forschung; National Breast Cancer Foundation; Breast Cancer Research Trust; Cancer Institute NSW; National Health and Medical Research Council; Cancer Research UK; Deutsches Krebsforschungszentrum; Rutgers Cancer Institute of New Jersey; Cancer Council Tasmania; National Institutes of Health; Ovarian Cancer Research Fund; Canadian Institutes of Health Research; Oak Foundation","keywords":"Single-nucleotide polymorphism; SNP; Minor allele frequency; Allele; Serous fluid; Breast cancer; Biology; Ovarian cancer; Locus (genetics); Promoter; Genotype; Genetics; Cancer research; Gene; Oncology; Medicine; Cancer; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002750139,0.0002431677,0.0002377003,0.0004683506,0.0001192888,0.0002248246,0.00016876,0.0002622738,0.002257328],"category_scores_gemma":[0.001148894,0.0001458634,0.0002486152,0.0004269663,0.0001854944,0.00007134651,0.0001896047,0.0002900579,0.0002638703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008875922,"about_ca_system_score_gemma":0.0001070826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008780897,"about_ca_topic_score_gemma":0.0007756907,"domain_scores_codex":[0.9997926,0.00006641229,0.00002420753,0.00004802884,0.00004398443,0.00002481629],"domain_scores_gemma":[0.999003,0.0002584156,0.0004535464,0.00007086518,0.00005557266,0.0001586706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004163885,0.0001800624,0.6918966,0.00009954191,0.0004964107,0.001568744,0.0002311705,0.000869537,0.2821239,0.000421861,0.0003831442,0.01756517],"study_design_scores_gemma":[0.0001228375,0.0003313819,0.9682146,0.00002224866,0.0002366656,0.005313127,0.00009471081,0.001792135,0.02225764,0.0006275857,0.0009709398,0.00001612857],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986278,0.0003062455,0.0005118391,0.00006359199,0.000005543052,0.000002856692,0.0001831084,0.00001858709,0.0002803475],"genre_scores_gemma":[0.9991021,0.0001000306,0.0003561967,0.00001744284,0.000006614391,0.000003119936,0.0001590287,0.000006465569,0.0002489314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002257328,"threshold_uncertainty_score":0.007551491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0171223825523287,"score_gpt":0.1690000925799683,"score_spread":0.1518777100276396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}