{"id":"W2092392561","doi":"10.1097/00005344-200036051-00096","title":"The Endothelin-A-Receptor Antagonist PD180988 (CI-1034) Selectively Reverses the Pulmonary Vasoconstrictor Response to Hypoxia in the Lamb","year":2000,"lang":"en","type":"article","venue":"Journal of Cardiovascular Pharmacology","topic":"Neuroscience of respiration and sleep","field":"Neuroscience","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Alberta","funders":"","keywords":"Hypoxic pulmonary vasoconstriction; Hypoxia (environmental); Pulmonary hypertension; Vasoconstriction; Medicine; Endothelin receptor; Endothelin receptor antagonist; Antagonist; Contractility; Endothelin 1; Internal medicine; Bolus (digestion); Vasoconstrictor Agents; Cardiology; Anesthesia; Receptor; Chemistry; Oxygen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005342945,0.0002269205,0.0003934897,0.0001970629,0.000872545,0.0002066382,0.001583601,0.0000733301,0.0003044484],"category_scores_gemma":[0.001188937,0.0001136473,0.0007447455,0.001099261,0.0005424616,0.0002642086,0.00007133799,0.0008175946,0.0001574037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001176052,"about_ca_system_score_gemma":0.0003217408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007764706,"about_ca_topic_score_gemma":0.000001664995,"domain_scores_codex":[0.9921824,0.005253557,0.0006093956,0.000357843,0.00107215,0.0005247076],"domain_scores_gemma":[0.9964975,0.002562087,0.0002237236,0.0004235328,0.0001448345,0.0001482857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002392259,0.0001759083,0.0000549294,0.000003253226,0.0001462373,0.00078288,0.0004655301,0.002611225,0.9199144,0.00005403122,0.02172345,0.05167585],"study_design_scores_gemma":[0.0009011477,0.0002917663,0.0008136486,0.000005910725,0.0001102918,0.001737824,0.000182546,0.0001116741,0.138412,0.00002450076,0.8572813,0.0001273352],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9642155,0.004045569,0.00018725,0.02556453,0.002483765,0.001204267,0.00003237827,0.00002958402,0.002237144],"genre_scores_gemma":[0.9752662,0.004181646,0.00003939604,0.01865351,0.0007490752,0.0000552739,1.474237e-7,0.00002468607,0.001030029],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8355579,"threshold_uncertainty_score":0.6710998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02104132812408274,"score_gpt":0.2834188308847873,"score_spread":0.2623775027607046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}