{"id":"W2092410819","doi":"10.1021/ja103153t","title":"pH-Responsive Molecular Tweezers","year":2010,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Queen's University","funders":"","keywords":"Chemistry; Molecular tweezers; Tweezers; Substrate (aquarium); Macromolecule; Optical tweezers; Conformational change; Force spectroscopy; Aqueous solution; Fluorescence; Aqueous medium; Molecular dynamics; Molecular switch; Biophysics; Supramolecular chemistry; Molecule; Stereochemistry; Organic chemistry; Computational chemistry; Biochemistry; Physical chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002171143,0.0001157573,0.0002076728,0.00001122142,0.00005165694,0.00001380712,0.0003676278,0.00008133018,0.000001465536],"category_scores_gemma":[0.0002577424,0.00007168872,0.000697444,0.0001831205,0.0005384229,0.000002850571,0.0001250558,0.0003970804,4.808334e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000175435,"about_ca_system_score_gemma":0.00006646774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004355346,"about_ca_topic_score_gemma":7.774885e-7,"domain_scores_codex":[0.999226,0.00003867414,0.0002300209,0.0001375179,0.0002048501,0.0001628903],"domain_scores_gemma":[0.9989353,0.00002063257,0.0004858407,0.0002919281,0.0001871092,0.00007913497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005238713,0.00003115831,0.0003702315,0.000001390096,0.0001042659,0.00000171413,0.00001359158,0.000002024294,0.9926688,0.000004902758,0.004490305,0.002259193],"study_design_scores_gemma":[0.0001310033,0.00008351439,0.0002813891,0.000007140524,0.00005177485,0.00008742561,0.00008966387,0.00001003772,0.988571,0.0001386525,0.0104461,0.000102296],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997524,0.00005703273,0.000724262,0.001486147,0.00008335154,0.00003354192,0.000003296232,0.00000679507,0.00008154205],"genre_scores_gemma":[0.9791366,0.00007643443,0.01843169,0.001992218,0.0002849329,6.024354e-7,0.000001367737,0.00001281488,0.00006328167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01838737,"threshold_uncertainty_score":0.2923381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004104024114990552,"score_gpt":0.2648308132041737,"score_spread":0.2607267890891831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}