{"id":"W2092410819","doi":"10.1021/ja103153t","title":"pH-Responsive Molecular Tweezers","year":2010,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Queen's University","funders":"","keywords":"Chemistry; Molecular tweezers; Tweezers; Substrate (aquarium); Macromolecule; Optical tweezers; Conformational change; Force spectroscopy; Aqueous solution; Fluorescence; Aqueous medium; Molecular dynamics; Molecular switch; Biophysics; Supramolecular chemistry; Molecule; Stereochemistry; Organic chemistry; Computational chemistry; Biochemistry; Physical chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001439971,0.0002777493,0.0001717577,0.0001420568,0.0001241586,0.0002647432,0.0003349753,0.000518621,0.001198975],"category_scores_gemma":[0.0002977989,0.0001175796,0.0001215393,0.00009424164,0.0002714314,0.0005889943,0.0003059708,0.0005220922,0.0004594145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002543658,"about_ca_system_score_gemma":0.0001196548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000219441,"about_ca_topic_score_gemma":0.0002598894,"domain_scores_codex":[0.9998423,0.0000211664,0.000008775201,0.00004130741,0.00005812516,0.00002821502],"domain_scores_gemma":[0.9998924,0.00003407885,0.00003241268,0.000006791884,0.00001752384,0.00001682128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002075512,0.000004885101,0.00002612724,0.00003469959,0.000001677076,0.0000431904,0.00001249385,0.0000758975,0.9977101,0.0003674352,0.00006336522,0.001639341],"study_design_scores_gemma":[0.000009416503,0.00006340275,0.0001552588,0.000002701215,0.00000391112,0.0001406014,0.00000880708,0.0009044913,0.9953141,0.00008068996,0.003309398,0.000007212368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9163921,0.008186003,0.06520411,0.001041054,0.0002888078,0.0001622637,0.0002882311,0.0005860915,0.007851409],"genre_scores_gemma":[0.9645269,0.002829936,0.02249354,0.000300349,0.0001033265,0.00009133192,0.0001554852,0.00003131189,0.009467862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001198975,"threshold_uncertainty_score":0.004010975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004104024114990552,"score_gpt":0.2648308132041737,"score_spread":0.2607267890891831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}